4-[(5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid

Base Information

• Chemical Name: 4-[(5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid
• CAS No.: 1364612-29-2
• Molecular Formula: C₃₂H₂₉Cl₂F₂N₃O₄
• Molecular Weight: 628.503

Synonyms:4-[(5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid

Chemical Property of 4-[(5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid

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Technology Process of 4-[(5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid

There total 1 articles about 4-[(5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-{[(2R,3S,4R,5S)-4-(4-Chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid (1229705-06-9) → 4-[(5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid (1364612-29-2)

Guidance literature:

In tetrahydrofuran; water; at 85 ℃;

Reference yield: 77.0%

4-[(5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzoic acid (1364612-29-2) → 4-[(5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzamide (1364612-62-3)

Guidance literature:

With ammonia; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

formaldehyd

4-{[(2R,3S,4R,5S)-4-(4-Chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid

Downstream raw materials:

4-[(5S,6R,7S,7aR)-7-(3-chloro-2-fluorophenyl)-6-(4-chloro-2-fluorophenyl)-6-cyano-5-(2,2-dimethylpropyl)-1-oxo-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-3-methoxybenzamide

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