C₂₂H₂₁F₂NO₆S₂

Base Information

• Chemical Name: C₂₂H₂₁F₂NO₆S₂
• CAS No.: 1100361-58-7
• Molecular Formula: C₂₂H₂₁F₂NO₆S₂
• Molecular Weight: 497.541
• Mol file: 1100361-58-7.mol

Synonyms:C₂₂H₂₁F₂NO₆S₂

Chemical Property of C₂₂H₂₁F₂NO₆S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₁F₂NO₆S₂

There total 9 articles about C₂₂H₂₁F₂NO₆S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-propane-1,3-diol (944950-53-2) → C22H21F2NO6S2 (1100361-58-7)

Guidance literature:

Multi-step reaction with 12 steps

1: potassium tert-butylate / tetrahydrofuran

2: Dess-Martin periodane / dichloromethane

3: trimethylsilyl trifluoromethanesulfonate

4: boron trifluoride diethyl etherate / dichloromethane

5: oxone / acetone; water

6: triethylamine / dichloromethane

7: potassium tert-butylate / tetrahydrofuran

8: ozone / dichloromethane

9: Resolution of racemate

10: zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 150 °C

11: triethylamine

12: tetra-(n-butyl)ammonium iodide / tetrahydrofuran

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; oxone; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; Dess-Martin periodane; ozone; triethylamine; zinc; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.bmcl.2012.11.047

Reference yield:

2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-malonic acid dimethyl ester (944950-34-9) → C22H21F2NO6S2 (1100361-58-7)

Guidance literature:

Multi-step reaction with 13 steps

1: lithium aluminium tetrahydride / tetrahydrofuran

2: potassium tert-butylate / tetrahydrofuran

3: Dess-Martin periodane / dichloromethane

4: trimethylsilyl trifluoromethanesulfonate

5: boron trifluoride diethyl etherate / dichloromethane

6: oxone / acetone; water

7: triethylamine / dichloromethane

8: potassium tert-butylate / tetrahydrofuran

9: ozone / dichloromethane

10: Resolution of racemate

11: zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 150 °C

12: triethylamine

13: tetra-(n-butyl)ammonium iodide / tetrahydrofuran

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; oxone; lithium aluminium tetrahydride; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; Dess-Martin periodane; ozone; triethylamine; zinc; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.bmcl.2012.11.047

Reference yield:

C21H21ClF2O5S → C22H21F2NO6S2 (1100361-58-7)

Guidance literature:

Multi-step reaction with 7 steps

1: triethylamine / dichloromethane

2: potassium tert-butylate / tetrahydrofuran

3: ozone / dichloromethane

4: Resolution of racemate

5: zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 150 °C

6: triethylamine

7: tetra-(n-butyl)ammonium iodide / tetrahydrofuran

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; ozone; triethylamine; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.11.047

upstream raw materials:

C₂₈H₂₅F₂NO₇S₂

sodium methansulfinate

2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-propane-1,3-diol

2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-malonic acid dimethyl ester

Downstream raw materials:

C₂₂H₂₁F₂NO₇S₂