2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-propane-1,3-diol

Base Information

Chemical Name:2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-propane-1,3-diol
CAS No.:944950-53-2
Molecular Formula:C₁₆H₁₄ClF₃O₂S
Molecular Weight:362.8
Hs Code.:

Synonyms:2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-propane-1,3-diol

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Chemical Property of 2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-propane-1,3-diol

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Technology Process of 2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-propane-1,3-diol

There total 3 articles about 2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 944950-34-9
2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-malonic acid dimethyl ester

: 944950-53-2
2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-propane-1,3-diol

Guidance literature:: 2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-malonic acid dimethyl ester; With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at 20 - 60 ℃; for 8h;

With hydrogenchloride; In tetrahydrofuran; hexane; water; ethyl acetate;

Reference yield:

: 944950-33-8
2-(2,3,6-trifluoro-benzylidene)-malonic acid dimethyl ester

: 944950-53-2
2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-propane-1,3-diol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrahydrofuran

2: lithium aluminium tetrahydride / tetrahydrofuran

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; 1: |Michael Addition;
DOI:10.1016/j.bmcl.2012.11.047

Reference yield:

: 106-54-7
p-Chlorothiophenol

: 944950-53-2
2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-propane-1,3-diol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrahydrofuran

2: lithium aluminium tetrahydride / tetrahydrofuran

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; 1: |Michael Addition;
DOI:10.1016/j.bmcl.2012.11.047