N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

Base Information

Chemical Name:N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide
CAS No.:582295-70-3
Molecular Formula:C₄₂H₄₁N₅O₈
Molecular Weight:743.816
Hs Code.:

<i>N</i>-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-<i>d</i>][1,3]dioxol-4-yl)-9<i>H</i>-purin-6-yl]-benzamide

Synonyms:N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

There total 5 articles about N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 582295-69-0
N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(2,2-dimethyl-6-triisopropylsilanyloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

: 582295-70-3
N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1039/b300932g

Reference yield:

: 39947-04-1
N-6-benzoyl-2',3'-O-isopropylideneadenosine

: 582295-70-3
N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / 1H-imidazole; DMAP / CH₂Cl₂ / 3 h / 23 °C

2: 94 percent / EtNiPr₂; DMAP / CH₂Cl₂ / 3 h / 50 °C

3: 89 percent / Bu₄NF*3H₂O / tetrahydrofuran / 4 h / 23 °C

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/hlca.200490204

Reference yield:

: 582295-68-9
N⁶-benzoyl-8-(hydroxymethyl)-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)adenosine

: 582295-70-3
N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / EtNiPr₂; DMAP / CH₂Cl₂ / 3 h / 50 °C

2: 89 percent / Bu₄NF*3H₂O / tetrahydrofuran / 4 h / 23 °C

With dmap; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/hlca.200490204