582295-68-9

Upstream product

• 13154-24-0 triisopropylsilyl chloride 
• 39947-04-1 N-6-benzoyl-2',3'-O-isopropylideneadenosine 
• 582295-67-8 N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)adenosine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 582295-69-0 N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(2,2-dimethyl-6-triisopropylsilanyloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide 
• 582295-71-4 C₆₄H₇₇N₇O₁₄Si 
• 582295-70-3 N-[8-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-9-(6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide 

Relevant academic research and scientific papers

Oligonucleotide analogues with a 'nucleobase-including backbone': Part 10 - Design, synthesis, and association of ether-linked dimers

The dinucleoside analogues 24, 25, 28-30, and 33 associate in CDCl 3 solution. Association constants, as determined from the concentration-dependent chemical shift for H-N(3) of the uridine moiety and from thermodynamic parameters, range from 265 M-1 (33) to 3220 M -1 (30). The association of 31 in CDCl3 is too strong to be determined (concentration independent δ5(H-N(3)) of ca. 12.8 ppm) and the fully deprotected dimer 32 proved insufficiently soluble in CDCl 3. This observation strongly evidences that structural differentiation of oligonucleotides and their analogues into backbone and nucleobases is not required for pairing. The dinucleotide analogues were prepared by O-alkylation of C(8)-unsubstituted or of C(8)-oxymethylated, partially protected adenosines by the C(6)-mesyloxy- or C(6)-halomethylated uridines 20-22, followed by partial or total deprotection.

Oligonucleosides with a nucleobase-including backbone; synthesis and self-association of novel dinucleotide analogues.

The synthesis and self-association of protected oxymethylene-bridged UA analogues are described.