(S)‐1‐(4‐methoxyphenyl)propan‐2‐amine

Base Information

• Chemical Name: (S)‐1‐(4‐methoxyphenyl)propan‐2‐amine
• CAS No.: 1194056-02-4
• Molecular Formula: C₉H₁₂FN
• Molecular Weight: 153.199
• Mol file: 1194056-02-4.mol

Synonyms:(S)‐1‐(4‐methoxyphenyl)propan‐2‐amine

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Chemical Property of (S)‐1‐(4‐methoxyphenyl)propan‐2‐amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)‐1‐(4‐methoxyphenyl)propan‐2‐amine

There total 2 articles about (S)‐1‐(4‐methoxyphenyl)propan‐2‐amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-fluorophenyl)acetone (1737-19-5) → (S)‐1‐(4‐methoxyphenyl)propan‐2‐amine (1194056-02-4)

Guidance literature:

With Brevibacterium epidermidis ECU₁₀₁₅; ammonium chloride; In aq. phosphate buffer; dimethyl sulfoxide; at 30 ℃; for 30h; pH=7.5; Sealed tube; Enzymatic reaction;

DOI:10.1016/S1872-2067(18)63108-0

Reference yield:

(±)-1-(3-fluorophenyl)propan-2-amine (1626-71-7) → (S)‐1‐(4‐methoxyphenyl)propan‐2‐amine (1194056-02-4) + 3-fluoroamphetamine (1335366-28-3)

Guidance literature:

With column LiChrospher 100 RP-18e; sulfated β-cyclodextrin; In methanol; water; at 20 ℃; Reagent/catalyst;

DOI:10.1002/chir.22341

upstream raw materials:

(±)-1-(3-fluorophenyl)propan-2-amine

(3-fluorophenyl)acetone

Refernces

• 1、 Li, Qing-Hua,Dong, Yuan,Chen, Fei-Fei,Liu, Lei,Li, Chun-Xiu,Xu, Jian-He,Zheng, Gao-Wei. "Reductive amination of ketones with ammonium catalyzed by a newly identified Brevibacterium epidermidis strain for the synthesis of (S)-chiral amines". . p. 1625 - 1632. Retrieved 2018/08/21.
• 2、 Taschwer, Magdalena,Seidl, Yvonne,Mohr, Stefan,Schmid, Martin G.. "Chiral separation of cathinone and amphetamine derivatives by HPLC/UV using sulfated β-cyclodextrin as chiral mobile phase additive". . p. 411 - 418. Retrieved 2014/08/05.