ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate

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Chemical Name:ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate
CAS No.:1364599-72-3
Molecular Formula:C₁₈H₁₇Cl₂N₃O₃
Molecular Weight:394.257
Hs Code.:

Synonyms:ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate

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Chemical Property of ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate

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Technology Process of ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate

There total 4 articles about ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.9%

: 1364599-70-1
ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

: 1364599-72-3
ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate

Guidance literature:: ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)acetate; With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 0.833333h;

With N-(benzenesulfonyl)-3-phenyloxaziridine; In tetrahydrofuran; at -78 ℃; for 2.5h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield:

: 1115-30-6
diethyl acetylsuccinate

: 1364599-72-3
ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / o-xylene / 2 h / 120 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 3 h / 120 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.83 h / -78 °C

3.2: 2.5 h / -78 °C

With potassium hexamethylsilazane; N,N-dimethyl-aniline; trichlorophosphate; toluene-4-sulfonic acid; In tetrahydrofuran; o-xylene;

Reference yield:

: 1187767-15-2
3-(3-chlorophenyl)-4-methyl-1H-pyrazol-5-amine

: 1364599-72-3
ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / o-xylene / 2 h / 120 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 3 h / 120 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.83 h / -78 °C

3.2: 2.5 h / -78 °C

With potassium hexamethylsilazane; N,N-dimethyl-aniline; trichlorophosphate; toluene-4-sulfonic acid; In tetrahydrofuran; o-xylene;