ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-oxoacetate

Base Information

Chemical Name:ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-oxoacetate
CAS No.:1364599-74-5
Molecular Formula:C₁₈H₁₅Cl₂N₃O₃
Molecular Weight:392.241
Hs Code.:

Synonyms:ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-oxoacetate

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Chemical Property of ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-oxoacetate

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Technology Process of ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-oxoacetate

There total 5 articles about ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.4%

: 1364599-72-3
ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxy acetate

: 1364599-74-5
ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-oxoacetate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; for 1h;

Reference yield:

: 1115-30-6
diethyl acetylsuccinate

: 1364599-74-5
ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-oxoacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / o-xylene / 2 h / 120 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 3 h / 120 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.83 h / -78 °C

3.2: 2.5 h / -78 °C

4.1: Dess-Martin periodane / dichloromethane / 1 h

With potassium hexamethylsilazane; Dess-Martin periodane; N,N-dimethyl-aniline; trichlorophosphate; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; o-xylene;

Reference yield:

: 1187767-15-2
3-(3-chlorophenyl)-4-methyl-1H-pyrazol-5-amine

: 1364599-74-5
ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-oxoacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / o-xylene / 2 h / 120 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 3 h / 120 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.83 h / -78 °C

3.2: 2.5 h / -78 °C

4.1: Dess-Martin periodane / dichloromethane / 1 h

With potassium hexamethylsilazane; Dess-Martin periodane; N,N-dimethyl-aniline; trichlorophosphate; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; o-xylene;