trans-6-benzylamino-2,2'-dimethyl-1,3-dioxocycloheptan-5-ol

Base Information

• Chemical Name: trans-6-benzylamino-2,2'-dimethyl-1,3-dioxocycloheptan-5-ol
• CAS No.: 1036765-71-5
• Molecular Formula: C₁₄H₂₁NO₃
• Molecular Weight: 251.326
• Mol file: 1036765-71-5.mol

Synonyms:trans-6-benzylamino-2,2'-dimethyl-1,3-dioxocycloheptan-5-ol

Chemical Property of trans-6-benzylamino-2,2'-dimethyl-1,3-dioxocycloheptan-5-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of trans-6-benzylamino-2,2'-dimethyl-1,3-dioxocycloheptan-5-ol

There total 5 articles about trans-6-benzylamino-2,2'-dimethyl-1,3-dioxocycloheptan-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]-octane (57280-22-5) + benzylamine (100-46-9) → trans-6-benzylamino-2,2'-dimethyl-1,3-dioxocycloheptan-5-ol (1036765-71-5)

Guidance literature:

benzylamine; With titanium(IV) isopropylate; (R)-1,1'-Bi-2-naphthol; (R)-6,6'-dibromo-1,1'-binaphth-2-ol; In toluene; at 20 ℃; for 0.5h;

4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]-octane; With water; In toluene; at 40 ℃; for 12h; optical yield given as %ee;

DOI:10.1021/ja801847r

Reference yield: 97.0%

4,4-dimethyl-3,5,8-trioxa-bicyclo-[5.1.0]octane (100572-41-6) + benzylamine (100-46-9) → trans-6-benzylamino-2,2'-dimethyl-1,3-dioxocycloheptan-5-ol (1036765-71-5)

Guidance literature:

With polymeric scandium biphenyl-4,4'-disulfonic acid; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.3987/COM-08-S(F)78

Reference yield:

4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]-octane (57280-22-5) + benzylamine (100-46-9) → trans-6-benzylamino-2,2'-dimethyl-1,3-dioxocycloheptan-5-ol (1036765-71-5) + (5R,6S)-6-(benzylamino)-2,2-dimethyl-1,3-dioxepan-5-ol

Guidance literature:

benzylamine; With titanium(IV) isopropylate; (R)-1,1'-Bi-2-naphthol; (R)-3,3'-diiodo-2,2'-dihydroxy-1,1'-binaphthyl; In toluene; at 20 ℃; for 0.5h;

4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]-octane; With water; In toluene; at 40 ℃; for 12h; optical yield given as %ee;

DOI:10.1021/ja801847r

upstream raw materials:

4,4-dimethyl-3,5,8-trioxa-bicyclo-[5.1.0]octane

benzylamine

4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]-octane

2,2-dimethyl-4,7-dihydro-1,3-dioxepin

Downstream raw materials:

(5S,6R)-6-(N-benzylacetamido)-2,2-dimethyl-1,3-dioxepan-5-yl acetate.