N-(2,2-difluoro-3-oxo-1-phenyl-3-trimethylsilylpropyl)-4-nitrobenzenesulfonamide

Base Information

• Chemical Name: N-(2,2-difluoro-3-oxo-1-phenyl-3-trimethylsilylpropyl)-4-nitrobenzenesulfonamide
• CAS No.: 866488-66-6
• Molecular Formula: C₁₈H₂₀F₂N₂O₅SSi
• Molecular Weight: 442.516
• Mol file: 866488-66-6.mol

Synonyms:N-(2,2-difluoro-3-oxo-1-phenyl-3-trimethylsilylpropyl)-4-nitrobenzenesulfonamide

Chemical Property of N-(2,2-difluoro-3-oxo-1-phenyl-3-trimethylsilylpropyl)-4-nitrobenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2,2-difluoro-3-oxo-1-phenyl-3-trimethylsilylpropyl)-4-nitrobenzenesulfonamide

There total 1 articles about N-(2,2-difluoro-3-oxo-1-phenyl-3-trimethylsilylpropyl)-4-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-phenylmethylene-4-nitrobenzenesulfonamide + 1,1-difluoro-2-trimethylsilyl-2-trimethylsilyloxyethene (731851-57-3) → N-(2,2-difluoro-3-oxo-1-phenyl-3-trimethylsilylpropyl)-4-nitrobenzenesulfonamide (866488-66-6)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/jo050953l

Reference yield:

N-(2,2-difluoro-3-oxo-1-phenyl-3-trimethylsilylpropyl)-4-nitrobenzenesulfonamide (866488-66-6) → 2,2-difluoro-3-(4-nitro-benzenesulfonylamino)-3-phenyl-propionic acid

Guidance literature:

With tetrabutyl ammonium fluoride; dihydrogen peroxide; In tetrahydrofuran; at 20 ℃; for 0.166667h;

DOI:10.1021/jo050953l

Reference yield:

N-(2,2-difluoro-3-oxo-1-phenyl-3-trimethylsilylpropyl)-4-nitrobenzenesulfonamide (866488-66-6) → N-ethyl-2,2-difluoro-3-amino-3-phenylpropionamide

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen peroxide; tetrabutylammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

2: chlorotrimethylsilane / 5 h / Heating

3: 96 percent / tetrahydrofuran / 24 h / 20 °C

4: 91 percent / thiophenol; potassium carbonate / dimethylformamide / 6 h / 20 °C

With chloro-trimethyl-silane; tetrabutyl ammonium fluoride; dihydrogen peroxide; potassium carbonate; thiophenol; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jo050953l

upstream raw materials:

1,1-difluoro-2-trimethylsilyl-2-trimethylsilyloxyethene

Downstream raw materials:

2,2-difluoro-3-(4-nitrobenzenesulfonylamino)-3-phenylpropionic acid ethyl ester

N-ethyl-2,2-difluoro-3-(4-nitrobenzenesulfonylamino)-3-phenylpropionamide