N-ethyl-2,2-difluoro-3-(4-nitrobenzenesulfonylamino)-3-phenylpropionamide

Base Information

• Chemical Name: N-ethyl-2,2-difluoro-3-(4-nitrobenzenesulfonylamino)-3-phenylpropionamide
• CAS No.: 866488-79-1
• Molecular Formula: C₁₇H₁₇F₂N₃O₅S
• Molecular Weight: 413.402
• Mol file: 866488-79-1.mol

Synonyms:N-ethyl-2,2-difluoro-3-(4-nitrobenzenesulfonylamino)-3-phenylpropionamide

Chemical Property of N-ethyl-2,2-difluoro-3-(4-nitrobenzenesulfonylamino)-3-phenylpropionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-ethyl-2,2-difluoro-3-(4-nitrobenzenesulfonylamino)-3-phenylpropionamide

There total 3 articles about N-ethyl-2,2-difluoro-3-(4-nitrobenzenesulfonylamino)-3-phenylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,2-difluoro-3-(4-nitrobenzenesulfonylamino)-3-phenylpropionic acid ethyl ester (866488-77-9) + ethylamine (75-04-7,85404-22-4) → N-ethyl-2,2-difluoro-3-(4-nitrobenzenesulfonylamino)-3-phenylpropionamide (866488-79-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1021/jo050953l

Reference yield:

2,2-difluoro-3-(4-nitro-benzenesulfonylamino)-3-phenyl-propionic acid → N-ethyl-2,2-difluoro-3-(4-nitrobenzenesulfonylamino)-3-phenylpropionamide (866488-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorotrimethylsilane / 5 h / Heating

2: 96 percent / tetrahydrofuran / 24 h / 20 °C

With chloro-trimethyl-silane; In tetrahydrofuran;

DOI:10.1021/jo050953l

Reference yield:

N-(2,2-difluoro-3-oxo-1-phenyl-3-trimethylsilylpropyl)-4-nitrobenzenesulfonamide (866488-66-6) → N-ethyl-2,2-difluoro-3-(4-nitrobenzenesulfonylamino)-3-phenylpropionamide (866488-79-1)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen peroxide; tetrabutylammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

2: chlorotrimethylsilane / 5 h / Heating

3: 96 percent / tetrahydrofuran / 24 h / 20 °C

With chloro-trimethyl-silane; tetrabutyl ammonium fluoride; dihydrogen peroxide; In tetrahydrofuran;

DOI:10.1021/jo050953l

upstream raw materials:

2,2-difluoro-3-(4-nitrobenzenesulfonylamino)-3-phenylpropionic acid ethyl ester

ethylamine

N-(2,2-difluoro-3-oxo-1-phenyl-3-trimethylsilylpropyl)-4-nitrobenzenesulfonamide