2-((2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)(pyridin-2-ylmethyl)amino)acetonitrile

Base Information

Chemical Name:2-((2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)(pyridin-2-ylmethyl)amino)acetonitrile
CAS No.:1236156-75-4
Molecular Formula:C₁₉H₁₈F₂N₆O
Molecular Weight:384.388
Hs Code.:

Synonyms:2-((2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)(pyridin-2-ylmethyl)amino)acetonitrile

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Chemical Property of 2-((2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)(pyridin-2-ylmethyl)amino)acetonitrile

Chemical Property:

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Technology Process of 2-((2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)(pyridin-2-ylmethyl)amino)acetonitrile

There total 2 articles about 2-((2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)(pyridin-2-ylmethyl)amino)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4377-33-7
2-chloromethylpyridine

: 1430334-36-3
C₁₃H₁₃F₂N₅O*ClH

: 1236156-75-4
2-((2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)(pyridin-2-ylmethyl)amino)acetonitrile

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; Reflux;
DOI:10.1016/j.cclet.2013.01.015

Reference yield:

: 86386-77-8
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate

: 1236156-75-4
2-((2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)(pyridin-2-ylmethyl)amino)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / Reflux

2: potassium iodide; potassium carbonate / acetonitrile / Reflux

With potassium carbonate; triethylamine; potassium iodide; In ethanol; acetonitrile;
DOI:10.1016/j.cclet.2013.01.015