Methanesulfonic acid 8-((2R,3R,4R,5S,6S)-4-allyloxy-3-benzyloxy-5-hydroxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-octyl ester

Base Information

Chemical Name:Methanesulfonic acid 8-((2R,3R,4R,5S,6S)-4-allyloxy-3-benzyloxy-5-hydroxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-octyl ester
CAS No.:213766-35-9
Molecular Formula:C₂₆H₄₂O₉S
Molecular Weight:530.68
Hs Code.:

Synonyms:Methanesulfonic acid 8-((2R,3R,4R,5S,6S)-4-allyloxy-3-benzyloxy-5-hydroxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-octyl ester

Suppliers and Price of Methanesulfonic acid 8-((2R,3R,4R,5S,6S)-4-allyloxy-3-benzyloxy-5-hydroxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-octyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methanesulfonic acid 8-((2R,3R,4R,5S,6S)-4-allyloxy-3-benzyloxy-5-hydroxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-octyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid 8-((2R,3R,4R,5S,6S)-4-allyloxy-3-benzyloxy-5-hydroxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-octyl ester

There total 11 articles about Methanesulfonic acid 8-((2R,3R,4R,5S,6S)-4-allyloxy-3-benzyloxy-5-hydroxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-octyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 124-63-0
methanesulfonyl chloride

: 213767-29-4
methyl 3-O-allyl-4-O-benzyl-6-O-(8'-hydroxyoctyl)-α-D-mannopyranoside

: 213766-35-9
Methanesulfonic acid 8-((2R,3R,4R,5S,6S)-4-allyloxy-3-benzyloxy-5-hydroxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-octyl ester

Guidance literature:: With pyridine; In dichloromethane; Ambient temperature;
DOI:10.1021/jo9806097

Reference yield:

: 629-41-4
1,8-Octanediol

: 213766-35-9
Methanesulfonic acid 8-((2R,3R,4R,5S,6S)-4-allyloxy-3-benzyloxy-5-hydroxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-octyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 55 percent / pyridine; CH₂Cl₂ / Ambient temperature

2: 82 percent / pyridine; CH₂Cl₂ / Ambient temperature

3: 84 percent / NaH / tetrahydrofuran / 1.) 50 deg C, 1 h, 2.) 65 deg C, 19 h

4: 80 percent / p-TsOH / methanol; ethyl acetate / 48 h

5: 1.) Bu₂SnO, 2.) Bu₄NI / 1.) MeOH, reflux, 2.3 h, 2.) tluene, 65 deg C, 15 h

6: 73 percent / pyridine / CH₂Cl₂ / Ambient temperature

With pyridine; tetra-(n-butyl)ammonium iodide; sodium hydride; di(n-butyl)tin oxide; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo9806097

Reference yield:

: 38257-96-4
8-[(triphenylmethyl)oxy]octanol

: 213766-35-9
Methanesulfonic acid 8-((2R,3R,4R,5S,6S)-4-allyloxy-3-benzyloxy-5-hydroxy-6-methoxy-tetrahydro-pyran-2-ylmethoxy)-octyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / pyridine; CH₂Cl₂ / Ambient temperature

2: 84 percent / NaH / tetrahydrofuran / 1.) 50 deg C, 1 h, 2.) 65 deg C, 19 h

3: 80 percent / p-TsOH / methanol; ethyl acetate / 48 h

4: 1.) Bu₂SnO, 2.) Bu₄NI / 1.) MeOH, reflux, 2.3 h, 2.) tluene, 65 deg C, 15 h

5: 73 percent / pyridine / CH₂Cl₂ / Ambient temperature

With pyridine; tetra-(n-butyl)ammonium iodide; sodium hydride; di(n-butyl)tin oxide; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo9806097