1-[3-acetoxy-3-(3,4-dimethoxyphenyl)-2-propyl]-4-(3-acetyl-2-keto-1-benzimidazolinyl)-piperidine

Base Information

Chemical Name:1-[3-acetoxy-3-(3,4-dimethoxyphenyl)-2-propyl]-4-(3-acetyl-2-keto-1-benzimidazolinyl)-piperidine
CAS No.:74179-09-2
Molecular Formula:C₂₇H₃₃N₃O₆
Molecular Weight:495.576
Hs Code.:

Synonyms:1-[3-acetoxy-3-(3,4-dimethoxyphenyl)-2-propyl]-4-(3-acetyl-2-keto-1-benzimidazolinyl)-piperidine

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Chemical Property of 1-[3-acetoxy-3-(3,4-dimethoxyphenyl)-2-propyl]-4-(3-acetyl-2-keto-1-benzimidazolinyl)-piperidine

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Technology Process of 1-[3-acetoxy-3-(3,4-dimethoxyphenyl)-2-propyl]-4-(3-acetyl-2-keto-1-benzimidazolinyl)-piperidine

There total 7 articles about 1-[3-acetoxy-3-(3,4-dimethoxyphenyl)-2-propyl]-4-(3-acetyl-2-keto-1-benzimidazolinyl)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74178-99-7
1-[3-hydroxy-3-(3,4-dimethoxyphenyl)-2-propyl]-4-(2-keto-1-benzimidazolinyl)-piperidine

: 74179-09-2
1-[3-acetoxy-3-(3,4-dimethoxyphenyl)-2-propyl]-4-(3-acetyl-2-keto-1-benzimidazolinyl)-piperidine

Guidance literature:: With dmap; acetic acid; triethylamine; In N-methyl-acetamide; water; ethyl acetate;

Reference yield:

: 1835-05-8
2-bromo-1-(3,4-dimethoxyphenyl)propan-1-one

: 74179-09-2,82454-28-2,82832-90-4,83708-98-9,83708-99-0
Acetic acid 2-[4-(3-acetyl-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidin-1-yl]-1-(3,4-dimethoxy-phenyl)-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 71.7 percent / Et₃N / methanol / 24 h / Ambient temperature

2: 69.1 percent / H₂ / PtO₂ / aq. acetic acid; methanol

3: 4-dimethylaminopyridine / dimethylformamide

With dmap; hydrogen; triethylamine; platinum(IV) oxide; In methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.30.462

Reference yield:

: 1835-04-7
ethyl 3,4-dimethoxyphenyl ketone

: 74179-09-2,82454-28-2,82832-90-4,83708-98-9,83708-99-0
Acetic acid 2-[4-(3-acetyl-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidin-1-yl]-1-(3,4-dimethoxy-phenyl)-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 54.9 percent / Br₂ / CHCl₃ / 1 h / Ambient temperature

2: 71.7 percent / Et₃N / methanol / 24 h / Ambient temperature

3: 69.1 percent / H₂ / PtO₂ / aq. acetic acid; methanol

4: 4-dimethylaminopyridine / dimethylformamide

With dmap; hydrogen; bromine; triethylamine; platinum(IV) oxide; In methanol; chloroform; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.30.462