4(R)-(tert-butyldiphenylsiloxy)-6(S)-<<2,4-dichloro-6-cyclohexylidenefluoromethyl)phenoxy>methyl>tetrahydropyran-2-one

Base Information

Chemical Name:4(R)-(tert-butyldiphenylsiloxy)-6(S)-<<2,4-dichloro-6-cyclohexylidenefluoromethyl)phenoxy>methyl>tetrahydropyran-2-one
CAS No.:136007-62-0
Molecular Formula:C₃₅H₃₉Cl₂FO₄Si
Molecular Weight:641.682
Hs Code.:

Synonyms:4(R)-(tert-butyldiphenylsiloxy)-6(S)-<<2,4-dichloro-6-cyclohexylidenefluoromethyl)phenoxy>methyl>tetrahydropyran-2-one

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Chemical Property of 4(R)-(tert-butyldiphenylsiloxy)-6(S)-<<2,4-dichloro-6-cyclohexylidenefluoromethyl)phenoxy>methyl>tetrahydropyran-2-one

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Technology Process of 4(R)-(tert-butyldiphenylsiloxy)-6(S)-<<2,4-dichloro-6-cyclohexylidenefluoromethyl)phenoxy>methyl>tetrahydropyran-2-one

There total 9 articles about 4(R)-(tert-butyldiphenylsiloxy)-6(S)-<<2,4-dichloro-6-cyclohexylidenefluoromethyl)phenoxy>methyl>tetrahydropyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 136007-46-0,136008-29-2
(4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-[2,4-dichloro-6-(cyclohexylidene-fluoro-methyl)-phenoxymethyl]-tetrahydro-pyran-2-ol

: 136007-62-0
4(R)-(tert-butyldiphenylsiloxy)-6(S)-<<2,4-dichloro-6-cyclohexylidenefluoromethyl)phenoxy>methyl>tetrahydropyran-2-one

Guidance literature:: With pyridine; chromium(VI) oxide; Celite; In dichloromethane; at 20 - 25 ℃; for 1h;
DOI:10.1021/jm00114a004

Reference yield:

: Cyclohexanecarboxylic acid 2,4-dichloro-phenyl ester

: 136007-62-0
4(R)-(tert-butyldiphenylsiloxy)-6(S)-<<2,4-dichloro-6-cyclohexylidenefluoromethyl)phenoxy>methyl>tetrahydropyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: AlCl₃ / 4 h / 150 °C

2: 47 percent / Et₂NSF₃ / toluene / 2 h / 25 °C

3: K₂CO₃, hydroquinone / dimethylsulfoxide / 1 h / 40 °C

4: glacial acetic acid / tetrahydrofuran / 72 h / Heating

5: CrO₃, pyridine, Celite / CH₂Cl₂ / 1 h / 20 - 25 °C

With pyridine; chromium(VI) oxide; aluminium trichloride; diethylamino-sulfur trifluoride; Celite; potassium carbonate; acetic acid; hydroquinone; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/jm00114a004

Reference yield:

: 136007-08-4
2,4-dichloro-6-(cyclohexylcarbonyl)phenol

: 136007-62-0
4(R)-(tert-butyldiphenylsiloxy)-6(S)-<<2,4-dichloro-6-cyclohexylidenefluoromethyl)phenoxy>methyl>tetrahydropyran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 47 percent / Et₂NSF₃ / toluene / 2 h / 25 °C

2: K₂CO₃, hydroquinone / dimethylsulfoxide / 1 h / 40 °C

3: glacial acetic acid / tetrahydrofuran / 72 h / Heating

4: CrO₃, pyridine, Celite / CH₂Cl₂ / 1 h / 20 - 25 °C

With pyridine; chromium(VI) oxide; diethylamino-sulfur trifluoride; Celite; potassium carbonate; acetic acid; hydroquinone; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/jm00114a004