(S)-benzyl-2-[bis((tert-butoxy)carbonyl)amino]-5-((tert-butyl)dimethylsilyloxy)pentanoate

Base Information

Chemical Name:(S)-benzyl-2-[bis((tert-butoxy)carbonyl)amino]-5-((tert-butyl)dimethylsilyloxy)pentanoate
CAS No.:1260112-25-1
Molecular Formula:C₂₈H₄₇NO₇Si
Molecular Weight:537.769
Hs Code.:

Synonyms:(S)-benzyl-2-[bis((tert-butoxy)carbonyl)amino]-5-((tert-butyl)dimethylsilyloxy)pentanoate

Suppliers and Price of (S)-benzyl-2-[bis((tert-butoxy)carbonyl)amino]-5-((tert-butyl)dimethylsilyloxy)pentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-benzyl-2-[bis((tert-butoxy)carbonyl)amino]-5-((tert-butyl)dimethylsilyloxy)pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-benzyl-2-[bis((tert-butoxy)carbonyl)amino]-5-((tert-butyl)dimethylsilyloxy)pentanoate

There total 3 articles about (S)-benzyl-2-[bis((tert-butoxy)carbonyl)amino]-5-((tert-butyl)dimethylsilyloxy)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 817166-98-6
(2S)-2-tert-butoxycarbonylamino-5-(tert-butyldimethyl-silanyloxy)-pentanoic acid benzyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 1260112-25-1
(S)-benzyl-2-[bis((tert-butoxy)carbonyl)amino]-5-((tert-butyl)dimethylsilyloxy)pentanoate

Guidance literature:: With dmap; In acetonitrile; at 20 ℃; for 24h;
DOI:10.1039/c0cc02889d

Reference yield:

: 30924-93-7
Boc-Glu-OBn

: 1260112-25-1
(S)-benzyl-2-[bis((tert-butoxy)carbonyl)amino]-5-((tert-butyl)dimethylsilyloxy)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 1 h / Inert atmosphere; Cooling with acetone-dry ice

1.2: 7 h / -15 - 20 °C

2.1: 1H-imidazole / dichloromethane / 0 - 20 °C

3.1: dmap / acetonitrile / 24 h / 20 °C

With 1H-imidazole; dmap; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1002/ejoc.201101757

Reference yield:

: 91229-97-9
(S)-2-[N-(tert-butoxycarbonyl)amino]-5-hydroxypentanoic acid benzyl ester

: 1260112-25-1
(S)-benzyl-2-[bis((tert-butoxy)carbonyl)amino]-5-((tert-butyl)dimethylsilyloxy)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / dichloromethane / 0 - 20 °C

2: dmap / acetonitrile / 24 h / 20 °C

With 1H-imidazole; dmap; In dichloromethane; acetonitrile;
DOI:10.1002/ejoc.201101757