817166-98-6

Upstream product

• 91229-97-9 (S)-2-[N-(tert-butoxycarbonyl)amino]-5-hydroxypentanoic acid benzyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 78658-49-8 Boc-Glu(OSu)-OBn 
• 30924-93-7 Boc-Glu-OBn 

Downstream Products

• 1260112-25-1 (S)-benzyl-2-[bis((tert-butoxy)carbonyl)amino]-5-((tert-butyl)dimethylsilyloxy)pentanoate 
• 817166-93-1 (2R,4R,5S)-2-benzyl-5-tert-butoxycarbonylamino-4-(tert-butyldimethylsilanyloxy)-7-(2,4,6-trimethoxybenzylcarbamoyl)heptanoic acid 
• 817167-06-9 C₃₅H₄₈N₂O₁₀ 
• 817167-07-0 [(1S)-1-[(4R)-4-benzyl-5-oxotetrahydrofuran-(2R)-2-yl]-3-(2,4,6-trimethoxybenzylcarbamoyl)propyl]carbamic acid tert-butyl ester 
• 817166-94-2 (2R,4R,5S)-2-benzyl-5-tert-butoxycarbonylamino-4,8-bis-(tert-butyldimethylsilanyloxy)octanoic acid 
• 817167-04-7 C₃₁H₅₁NO₇Si 
• 817166-95-3 [(1S)-1-[(4R)-4-benzyl-5-oxotetrahydrofuran-(2R)-2-yl]-4-(tert-butyldimethylsilanyloxy)butyl]carbamic acid tert-butyl ester 
• 817167-05-8 (4S)-4-[(4R)-4-benzyl-5-oxotetrahydrofuran-(2R)-2-yl]-4-[bis(tert-butoxycarbonyl)amino]butyric acid 
• 817167-02-5 [(1S)-1-[(4R)-4-benzyl-5-oxotetrahydrofuran-(2R)-2-yl]-4-hydroxybutyl]carbamic acid tert-butyl ester 
• 869190-22-7 (2S)-N'-[2-tert-butoxycarbonylamino-5-(tert-butyl-dimethyl-silanyloxy)-pentanoyl]-N-methyl-hydrazinecarboxylic acid benzyl ester 
• 869190-24-9 (2S)-N'-(2-tert-butoxycarbonylamino-5-hydroxy-pentanoyl)-N-methyl-hydrazinecarboxylic acid benzyl ester 

Relevant academic research and scientific papers

Development of a solid-phase approach to the natural product class of Ahp-containing cyclodepsipeptides

The 3-amino-6-hydroxy-2-piperidone (Ahp) containing cyclodepsipeptides are an interesting class of natural products that inhibit S1 (trypsin and chymotrypsin-like) serine protease in a reversible, noncovalent manner, turning them into potential chemical t

Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A

The solid phase total synthesis of the marine cyanobacterial Ahp-cyclodepsipeptide Symplocamide A is reported as a model for a general route for the synthesis of tailor-made non-covalent serine protease inhibitors. The Royal Society of Chemistry 2010.

A general strategy for the synthesis of azapeptidomimetic lactams

A selection of azapeptidomimetics containing constraining lactam rings have been prepared by Mitsunobu cyclization of serine/homologated serine-azaalanine derivatives. These include sterically-congested β-lactams, as well as γ-butyrolactam and δ-valerolac

Synthesis of a Gln-Phe hydroxy-ethylene dipeptide isostere

(Chemical Equation Presented) The protected Gln-Phe hydroxyethylene dipeptide isostere 1 was synthesized as a precursor for preparation of potential inhibitors of Botulinum neurotoxin B metalloprotease. The method allows for the synthesis of additional hydroxyethylene dipeptide isosteres such as 2 with functionalized P1 side chains. The isosteres prepared were coupled with a dipeptide to produce protected pseudotetrapeptide derivatives.