{3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-acetic acid

Base Information

Chemical Name:{3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-acetic acid
CAS No.:1026922-89-3
Molecular Formula:C₁₇H₂₂O₄
Molecular Weight:290.359
Hs Code.:

Synonyms:{3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-acetic acid

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Chemical Property of {3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-acetic acid

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Technology Process of {3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-acetic acid

There total 1 articles about {3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127980-37-4
{3-[2-((1S,2R,3R,4R)-3-Acetoxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-acetic acid methyl ester

: 1026922-89-3
{3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-acetic acid

Guidance literature:: With methanol; potassium carbonate; In acetone; at 0 ℃;
DOI:10.1021/jm00062a013

Reference yield:

: 1026922-89-3
{3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-acetic acid

: [3-(2-{(1S,2R,3S,4R)-3-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: diethyl ether / 25 °C

2: 1-hydroxybenzotriazole, Et₃N, ethyl (3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 0 - 25 °C

3: (iPr)2NEt / CH₂Cl₂ / 0 °C

4: K₂CO₃ / acetone / 65 °C

5: CuBr₂, DBU / ethyl acetate; CHCl₃ / 25 °C

6: LiOH / tetrahydrofuran; H₂O / 25 °C

With lithium hydroxide; potassium carbonate; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; copper(ll) bromide; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00062a013

Reference yield:

: 1026922-89-3
{3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-acetic acid

: 1027179-75-4
[3-(2-{(1S,2R,3S,4R)-3-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: diethyl ether / 25 °C

2: 1-hydroxybenzotriazole, Et₃N, ethyl (3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 0 - 25 °C

3: (iPr)2NEt / CH₂Cl₂ / 0 °C

4: K₂CO₃ / acetone / 65 °C

5: CuBr₂, DBU / ethyl acetate; CHCl₃ / 25 °C

With potassium carbonate; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; copper(ll) bromide; In diethyl ether; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00062a013