(2R,4R)-4-{[5-(azetidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}-5-biphenyl-4-yl-2-hydroxypentanoic acid trifluoroacetate

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Chemical Name:(2R,4R)-4-{[5-(azetidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}-5-biphenyl-4-yl-2-hydroxypentanoic acid trifluoroacetate
CAS No.:1383006-09-4
Molecular Formula:C₂HF₃O₂*C₂₅H₂₆N₄O₅
Molecular Weight:576.529
Hs Code.:

Synonyms:(2R,4R)-4-{[5-(azetidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}-5-biphenyl-4-yl-2-hydroxypentanoic acid trifluoroacetate

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Chemical Property of (2R,4R)-4-{[5-(azetidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}-5-biphenyl-4-yl-2-hydroxypentanoic acid trifluoroacetate

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Technology Process of (2R,4R)-4-{[5-(azetidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}-5-biphenyl-4-yl-2-hydroxypentanoic acid trifluoroacetate

There total 9 articles about (2R,4R)-4-{[5-(azetidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}-5-biphenyl-4-yl-2-hydroxypentanoic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383006-00-5
(2R,4R)-4-{[5-(azetidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}-5-biphenyl-4-yl-2-hydroxypentanoic acid ethyl ester trifluoroacetate

: 76-05-1
trifluoroacetic acid

: 1383006-09-4
(2R,4R)-4-{[5-(azetidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}-5-biphenyl-4-yl-2-hydroxypentanoic acid trifluoroacetate

Guidance literature:: (2R,4R)-4-{[5-(azetidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}-5-biphenyl-4-yl-2-hydroxypentanoic acid ethyl ester trifluoroacetate; With water; sodium hydroxide; In ethanol; for 1h;

With acetic acid; In ethanol;

trifluoroacetic acid;

Reference yield:

: 1383026-37-6
[(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester

: 1383006-09-4
(2R,4R)-4-{[5-(azetidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}-5-biphenyl-4-yl-2-hydroxypentanoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

1.2: 3 h / -5 °C

2.1: toluene / 3 h / Inert atmosphere; Reflux

3.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

4.2: 1 h / -78 °C

5.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

5.2: 0.5 h

6.1: hydrogenchloride / water / 20 h / 90 - 95 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

8.1: sodium hydroxide; water / ethanol / 1 h

With hydrogenchloride; n-butyllithium; water; sodium hexamethyldisilazane; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; hexanes; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 128779-47-5
(2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

: 1383006-09-4
(2R,4R)-4-{[5-(azetidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}-5-biphenyl-4-yl-2-hydroxypentanoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / -5 °C / Inert atmosphere

2.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

2.2: 3 h / -5 °C

3.1: toluene / 3 h / Inert atmosphere; Reflux

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 3.25 h / -65 °C / Inert atmosphere

4.2: 2 h / -35 °C

5.1: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5.2: 2.25 h / 0 °C

6.1: potassium carbonate / 20 h / 20 °C / Inert atmosphere

7.1: acetyl chloride / ethanol / 3 h / 25 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

9.1: sodium hydroxide; water / ethanol / 1 h

With dmap; water; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; acetyl chloride; dicyclohexyl-carbodiimide; HATU; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;