[(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester

Base Information

Chemical Name:[(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester
CAS No.:1383026-37-6
Molecular Formula:C₂₆H₂₉NO₇
Molecular Weight:467.519
Hs Code.:

Synonyms:[(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester

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Chemical Property of [(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester

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Technology Process of [(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester

There total 1 articles about [(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 2033-24-1
cycl-isopropylidene malonate

: 128779-47-5
(2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

: 1383026-37-6
[(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1383026-37-6
[(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester

: 1038924-61-6
(S)-5-biphenyl-4-ylmethylpyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

1.2: 3 h / -5 °C

2.1: toluene / 3 h / Inert atmosphere; Reflux

3.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

With hydrogenchloride; acetic acid; In dichloromethane; ethyl acetate; toluene;

Reference yield:

: 1383026-37-6
[(R)-1-biphenyl-4-ylmethyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-2-oxoethyl]carbamic acid t-butyl ester

: 1394050-29-3
C₂₄H₂₉NO₃

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

1.2: 2 h / -5 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 23 °C / Inert atmosphere

3.1: hydrogenchloride / cyclopentyl methyl ether / 24 h / 0 - 20 °C / Inert atmosphere

4.1: 2-methyltetrahydrofuran; cyclopentyl methyl ether / 20 °C / Inert atmosphere

5.1: 4-methyl-morpholine / tetrahydrofuran / 0.33 h / 0 - 5 °C / Inert atmosphere

6.1: sodium tetrahydroborate / water; tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

7.1: toluene-4-sulfonic acid / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; sodium tetrahydroborate; potassium carbonate; acetic acid; toluene-4-sulfonic acid; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; cyclopentyl methyl ether; water; N,N-dimethyl-formamide;