di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-{4-[2-(tosyloxy)ethoxy]benzyl}-hexanedioate

Base Information

Chemical Name:di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-{4-[2-(tosyloxy)ethoxy]benzyl}-hexanedioate
CAS No.:1407506-29-9
Molecular Formula:C₃₅H₅₁NO₁₀S
Molecular Weight:677.857
Hs Code.:

Synonyms:di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-{4-[2-(tosyloxy)ethoxy]benzyl}-hexanedioate

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Chemical Property of di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-{4-[2-(tosyloxy)ethoxy]benzyl}-hexanedioate

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Technology Process of di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-{4-[2-(tosyloxy)ethoxy]benzyl}-hexanedioate

There total 6 articles about di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-{4-[2-(tosyloxy)ethoxy]benzyl}-hexanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1407507-21-4
Di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-(4-hydroxybenzyl)hexane-dioate

: 6315-52-2
1,2-bis-tosyloxyethane

: 1407506-29-9
di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-{4-[2-(tosyloxy)ethoxy]benzyl}-hexanedioate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h;

Reference yield:

: 110207-49-3
tert-butyl D-N-(tert-butoxycarbonyl)homoserinate

: 1407506-29-9
di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-{4-[2-(tosyloxy)ethoxy]benzyl}-hexanedioate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / dichloromethane / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 60 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

3.2: 1 h / 60 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 2.5 h / 20 °C

5.1: dmap / tetrahydrofuran / 2 h / Reflux

6.1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C

With dmap; N-Bromosuccinimide; hydrogen; sodium hydride; caesium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1407507-33-8
di-tert-butyl (5R)-2-(benzyloxycarbonyl)-5-[(tert-butoxycarbonyl)amino]hexane-dioate

: 1407506-29-9
di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-{4-[2-(tosyloxy)ethoxy]benzyl}-hexanedioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

1.2: 1 h / 60 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 2.5 h / 20 °C

3.1: dmap / tetrahydrofuran / 2 h / Reflux

4.1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C

With dmap; hydrogen; sodium hydride; caesium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;