Di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-(4-hydroxybenzyl)hexane-dioate

Base Information

Chemical Name:Di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-(4-hydroxybenzyl)hexane-dioate
CAS No.:1407507-21-4
Molecular Formula:C₂₆H₄₁NO₇
Molecular Weight:479.614
Hs Code.:

Synonyms:Di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-(4-hydroxybenzyl)hexane-dioate

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Chemical Property of Di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-(4-hydroxybenzyl)hexane-dioate

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Technology Process of Di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-(4-hydroxybenzyl)hexane-dioate

There total 5 articles about Di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-(4-hydroxybenzyl)hexane-dioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1407507-35-0
(5R)-2-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-(4-hydroxybenzyl)hexanedioic acid 6-tert-butyl ester

: 1407507-21-4
Di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-(4-hydroxybenzyl)hexane-dioate

Guidance literature:: With dmap; In tetrahydrofuran; for 2h; Reflux;

Reference yield:

: 110207-49-3
tert-butyl D-N-(tert-butoxycarbonyl)homoserinate

: 1407507-21-4
Di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-(4-hydroxybenzyl)hexane-dioate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / dichloromethane / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 60 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

3.2: 1 h / 60 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 2.5 h / 20 °C

5.1: dmap / tetrahydrofuran / 2 h / Reflux

With dmap; N-Bromosuccinimide; hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 123004-74-0
tert-butyl D-2-<(tert-butoxycarbonyl)amino>-4-bromobutyrate

: 1407507-21-4
Di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-(4-hydroxybenzyl)hexane-dioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

1.2: 60 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

2.2: 1 h / 60 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 2.5 h / 20 °C

4.1: dmap / tetrahydrofuran / 2 h / Reflux

With dmap; hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;