1,3-di-O-benzyl-2-O-(2,3,4-tri-O-benzyl-6-O-trityl-β-D-galactopyranosyl)glycerol

Base Information

• Chemical Name: 1,3-di-O-benzyl-2-O-(2,3,4-tri-O-benzyl-6-O-trityl-β-D-galactopyranosyl)glycerol
• CAS No.: 444808-93-9
• Molecular Formula: C₆₃H₆₂O₈
• Molecular Weight: 947.18
• Mol file: 444808-93-9.mol

Synonyms:1,3-di-O-benzyl-2-O-(2,3,4-tri-O-benzyl-6-O-trityl-β-D-galactopyranosyl)glycerol

Chemical Property of 1,3-di-O-benzyl-2-O-(2,3,4-tri-O-benzyl-6-O-trityl-β-D-galactopyranosyl)glycerol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-di-O-benzyl-2-O-(2,3,4-tri-O-benzyl-6-O-trityl-β-D-galactopyranosyl)glycerol

There total 5 articles about 1,3-di-O-benzyl-2-O-(2,3,4-tri-O-benzyl-6-O-trityl-β-D-galactopyranosyl)glycerol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

benzyl chloride (100-44-7) + 1,3-di-O-benzyl-2-O-(6-O-trityl-β-D-galactopyranosyl)glycerol (444808-92-8) → 1,3-di-O-benzyl-2-O-(2,3,4-tri-O-benzyl-6-O-trityl-β-D-galactopyranosyl)glycerol (444808-93-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 55 ℃; for 0.5h;

DOI:10.1002/1099-0690(200204)2002:8<1429::AID-EJOC1429>3.0.CO;2-2

Reference yield:

dibenzyl glycerol (6972-79-8) → 1,3-di-O-benzyl-2-O-(2,3,4-tri-O-benzyl-6-O-trityl-β-D-galactopyranosyl)glycerol (444808-93-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: BF₃*OEt₂ / CH₂Cl₂ / 0 - 20 °C

1.2: 90 percent / NaOMe / methanol / 2 h

2.1: 80 percent / pyridine / 4 h / 55 °C

3.1: 94 percent / NaH / dimethylformamide / 0.5 h / 55 °C

With pyridine; boron trifluoride diethyl etherate; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; 1.2: Zemplen deacetylation;

DOI:10.1002/1099-0690(200204)2002:8<1429::AID-EJOC1429>3.0.CO;2-2

Reference yield:

trityl chloride (76-83-5) → 1,3-di-O-benzyl-2-O-(2,3,4-tri-O-benzyl-6-O-trityl-β-D-galactopyranosyl)glycerol (444808-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / pyridine / 4 h / 55 °C

2: 94 percent / NaH / dimethylformamide / 0.5 h / 55 °C

With pyridine; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1002/1099-0690(200204)2002:8<1429::AID-EJOC1429>3.0.CO;2-2

upstream raw materials:

benzyl chloride

1,3-di-O-benzyl-2-O-(6-O-trityl-β-D-galactopyranosyl)glycerol

dibenzyl glycerol

trityl chloride

Downstream raw materials:

1,3-di-O-benzyl-2-O-(2,3,4-tri-O-benzyl-6-O-hexyl-β-D-galactopyranosyl)glycerol

1,3-di-O-benzyl-2-O-[(6Z)-2,3,4-tri-O-benzyl-6,7,8,9,10,11,12,13-octadeoxy-β-D-galacto-tridec-6-enopyranosyl]glycerol

(2S,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-6-(2-benzyloxy-1-benzyloxymethyl-ethoxy)-tetrahydro-pyran-2-carbaldehyde

1,3-di-O-benzyl-2-O-(2,3,4-tri-O-benzyl-β-D-galactopyranosyl)-glycerol