3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridin-2-ylamine

Base Information

Chemical Name:3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridin-2-ylamine
CAS No.:930304-17-9
Molecular Formula:C₂₆H₂₃Br₂N₅O₂
Molecular Weight:597.309
Hs Code.:

Synonyms:3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridin-2-ylamine

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Chemical Property of 3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridin-2-ylamine

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Technology Process of 3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridin-2-ylamine

There total 16 articles about 3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 930304-16-8
2-azido-3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridine

: 930304-17-9
3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridin-2-ylamine

Guidance literature:: With hydrogen; Lindlar's catalyst; In tetrahydrofuran; methanol; at 20 ℃; for 17h;
DOI:10.1021/ol063038a

Reference yield:

: 930304-05-5
1-benzyloxymethyl-2-methylsulfanylimidazole-4-carbaldehyde

: 930304-17-9
3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 93 percent / t-BuOK / tetrahydrofuran / -78 - 20 °C

2.1: 92 percent / CuI; Cs₂CO₃; N,N'-dimethylethylenediamine / tetrahydrofuran / 17 h / 70 °C

3.1: 82 percent / Lawesson's reagent / toluene / 2 h / 100 °C

4.1: 93 percent / CH₂Cl₂ / 2 h / 20 °C

5.1: 12 percent / 1,3,5-trimethyl-benzene / 16 h / 145 °C

6.1: m-CPBA / CH₂Cl₂ / 1.58 h / -78 - 20 °C

6.2: 21 mg / NaN₃ / dimethylsulfoxide / 6 h / 20 °C

7.1: 94 percent / H₂ / Lindlar catalyst / methanol; tetrahydrofuran / 17 h / 20 °C

With Lawessons reagent; copper(l) iodide; potassium tert-butylate; hydrogen; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; N,N`-dimethylethylenediamine; Lindlar's catalyst; In tetrahydrofuran; methanol; dichloromethane; toluene; 1,3,5-trimethyl-benzene; 1.1: Wittig reaction;
DOI:10.1021/ol063038a

Reference yield:

: 930304-08-8
1-benzyloxymethylpyrrole-2-carboxylic acid amide

: 930304-17-9
3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 94 percent / NBS / tetrahydrofuran / 0.5 h / 20 °C

2.1: 92 percent / CuI; Cs₂CO₃; N,N'-dimethylethylenediamine / tetrahydrofuran / 17 h / 70 °C

3.1: 82 percent / Lawesson's reagent / toluene / 2 h / 100 °C

4.1: 93 percent / CH₂Cl₂ / 2 h / 20 °C

5.1: 12 percent / 1,3,5-trimethyl-benzene / 16 h / 145 °C

6.1: m-CPBA / CH₂Cl₂ / 1.58 h / -78 - 20 °C

6.2: 21 mg / NaN₃ / dimethylsulfoxide / 6 h / 20 °C

7.1: 94 percent / H₂ / Lindlar catalyst / methanol; tetrahydrofuran / 17 h / 20 °C

With Lawessons reagent; N-Bromosuccinimide; copper(l) iodide; hydrogen; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; N,N`-dimethylethylenediamine; Lindlar's catalyst; In tetrahydrofuran; methanol; dichloromethane; toluene; 1,3,5-trimethyl-benzene;
DOI:10.1021/ol063038a