2-azido-3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridine

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Chemical Name:2-azido-3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridine
CAS No.:930304-16-8
Molecular Formula:C₂₆H₂₁Br₂N₇O₂
Molecular Weight:623.306
Hs Code.:

Synonyms:2-azido-3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridine

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Chemical Property of 2-azido-3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridine

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Technology Process of 2-azido-3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridine

There total 15 articles about 2-azido-3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 930304-13-5
3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)-2-methylsulfanylimidazo[4,5-c]pyridine

: 930304-16-8
2-azido-3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridine

Guidance literature:: 3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)-2-methylsulfanylimidazo[4,5-c]pyridine; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -78 - 20 ℃; for 1.58333h;

With sodium azide; In dimethyl sulfoxide; at 20 ℃; for 6h;
DOI:10.1021/ol063038a

Reference yield:

: 930304-07-7
1-benzyloxymethylpyrrole-2-carbonitrile

: 930304-16-8
2-azido-3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 91 percent / Bu₄NHSO₄; aq. H₂O₂; NaOH / CH₂Cl₂ / 3 h / 20 °C

2.1: 94 percent / NBS / tetrahydrofuran / 0.5 h / 20 °C

3.1: 92 percent / CuI; Cs₂CO₃; N,N'-dimethylethylenediamine / tetrahydrofuran / 17 h / 70 °C

4.1: 82 percent / Lawesson's reagent / toluene / 2 h / 100 °C

5.1: 93 percent / CH₂Cl₂ / 2 h / 20 °C

6.1: 12 percent / 1,3,5-trimethyl-benzene / 16 h / 145 °C

7.1: m-CPBA / CH₂Cl₂ / 1.58 h / -78 - 20 °C

7.2: 21 mg / NaN₃ / dimethylsulfoxide / 6 h / 20 °C

With Lawessons reagent; sodium hydroxide; N-Bromosuccinimide; copper(l) iodide; dihydrogen peroxide; tetra(n-butyl)ammonium hydrogensulfate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; N,N`-dimethylethylenediamine; In tetrahydrofuran; dichloromethane; toluene; 1,3,5-trimethyl-benzene;
DOI:10.1021/ol063038a

Reference yield:

: 930304-08-8
1-benzyloxymethylpyrrole-2-carboxylic acid amide

: 930304-16-8
2-azido-3-benzyloxymethyl-4-(1-benzyloxymethyl-4,5-dibromopyrrol-2-yl)imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 94 percent / NBS / tetrahydrofuran / 0.5 h / 20 °C

2.1: 92 percent / CuI; Cs₂CO₃; N,N'-dimethylethylenediamine / tetrahydrofuran / 17 h / 70 °C

3.1: 82 percent / Lawesson's reagent / toluene / 2 h / 100 °C

4.1: 93 percent / CH₂Cl₂ / 2 h / 20 °C

5.1: 12 percent / 1,3,5-trimethyl-benzene / 16 h / 145 °C

6.1: m-CPBA / CH₂Cl₂ / 1.58 h / -78 - 20 °C

6.2: 21 mg / NaN₃ / dimethylsulfoxide / 6 h / 20 °C

With Lawessons reagent; N-Bromosuccinimide; copper(l) iodide; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; N,N`-dimethylethylenediamine; In tetrahydrofuran; dichloromethane; toluene; 1,3,5-trimethyl-benzene;
DOI:10.1021/ol063038a