(+)-2-(tert-butyldimethylsilyloxy)-3-[3-(tert-butyldimethylsilyloxy)-5-methylphenyl]propan-1-ol

Base Information

Chemical Name:(+)-2-(tert-butyldimethylsilyloxy)-3-[3-(tert-butyldimethylsilyloxy)-5-methylphenyl]propan-1-ol
CAS No.:745809-31-8
Molecular Formula:C₂₂H₄₂O₃Si₂
Molecular Weight:410.745
Hs Code.:

Synonyms:(+)-2-(tert-butyldimethylsilyloxy)-3-[3-(tert-butyldimethylsilyloxy)-5-methylphenyl]propan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-2-(tert-butyldimethylsilyloxy)-3-[3-(tert-butyldimethylsilyloxy)-5-methylphenyl]propan-1-ol

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Technology Process of (+)-2-(tert-butyldimethylsilyloxy)-3-[3-(tert-butyldimethylsilyloxy)-5-methylphenyl]propan-1-ol

There total 3 articles about (+)-2-(tert-butyldimethylsilyloxy)-3-[3-(tert-butyldimethylsilyloxy)-5-methylphenyl]propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 745809-53-4
(+)-1-[3-(tert-butyldimethylsilyloxy)-5-methylphenyl]-2-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)propane

: 745809-31-8
(+)-2-(tert-butyldimethylsilyloxy)-3-[3-(tert-butyldimethylsilyloxy)-5-methylphenyl]propan-1-ol

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; for 1h; pH=7;
DOI:10.1021/jo049426c

Reference yield:

: 34946-83-3
2,4,4,6-tetrabromo-3-methyl-cyclohexa-2,5-dienone

: 745809-31-8
(+)-2-(tert-butyldimethylsilyloxy)-3-[3-(tert-butyldimethylsilyloxy)-5-methylphenyl]propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 57 percent / sulfuric acid / 16 h

2: 2,6-lutidine

3: 92 percent / DDQ; buffer / CH₂Cl₂; H₂O / 1 h / pH 7

With 2,6-dimethylpyridine; sulfuric acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water;
DOI:10.1021/jo049426c

Reference yield:

: 108-39-4
3-methyl-phenol

: 745809-31-8
(+)-2-(tert-butyldimethylsilyloxy)-3-[3-(tert-butyldimethylsilyloxy)-5-methylphenyl]propan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 52 percent / Br₂ / acetic acid

2: 57 percent / sulfuric acid / 16 h

3: 2,6-lutidine

4: 92 percent / DDQ; buffer / CH₂Cl₂; H₂O / 1 h / pH 7

With 2,6-dimethylpyridine; sulfuric acid; bromine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; acetic acid;
DOI:10.1021/jo049426c