Technology Process of (1S,2R,5S,7R)-7-(5-(benzyloxy)pentyl)-5-(15-hydroxypentadecyl)-6,8-dioxabicyclo[3.2.1]octan-2-yl benzoate
There total 15 articles about (1S,2R,5S,7R)-7-(5-(benzyloxy)pentyl)-5-(15-hydroxypentadecyl)-6,8-dioxabicyclo[3.2.1]octan-2-yl benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dichloro bis(acetonitrile) palladium(II);
In
acetonitrile;
at 20 ℃;
regioselective reaction;
Inert atmosphere;
DOI:10.1016/j.tet.2012.12.045
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sodium periodate / dichloromethane; water / 4 h / 0 - 20 °C
2.1: potassium tert-butylate / tetrahydrofuran / 0 °C
2.2: 0.5 h / 0 °C
3.1: hydrogen / ethanol / 0.5 h / 1034.32 Torr
4.1: toluene-4-sulfonic acid / methanol / 20 h / 0 °C
5.1: di(n-butyl)tin oxide; dmap; triethylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice
5.2: 4 h / 0 - 20 °C
6.1: potassium carbonate / methanol / 1 h / 0 °C / Inert atmosphere
7.1: n-butyllithium; boron trifluoride diethyl etherate / tetrahydrofuran / 0.75 h / -78 °C
8.1: dmap; triethylamine / dichloromethane / 0.25 h / 0 °C
8.2: 2 h / 0 °C
9.1: toluene-4-sulfonic acid / methanol / 2 h / 20 °C
10.1: dichloro bis(acetonitrile) palladium(II) / acetonitrile / 20 °C / Inert atmosphere
With
dmap; dichloro bis(acetonitrile) palladium(II); sodium periodate; n-butyllithium; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen; di(n-butyl)tin oxide; potassium carbonate; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile;
2.1: |Wittig Olefination / 2.2: |Wittig Olefination;
DOI:10.1016/j.tet.2012.12.045
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dmap; triethylamine / dichloromethane / 0.25 h / 0 °C
1.2: 1 h / 0 °C
2.1: n-butyllithium; boron trifluoride diethyl etherate / tetrahydrofuran / 0.75 h / -78 °C
3.1: dmap; triethylamine / dichloromethane / 0.25 h / 0 °C
3.2: 2 h / 0 °C
4.1: toluene-4-sulfonic acid / methanol / 2 h / 20 °C
5.1: dichloro bis(acetonitrile) palladium(II) / acetonitrile / 20 °C / Inert atmosphere
With
dmap; dichloro bis(acetonitrile) palladium(II); n-butyllithium; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2012.12.045
