2-tert-butyloxycarbonylaminomethyl-5-(3'-hydroxyphenylmethyl)nitrobenzene

Base Information

Chemical Name:2-tert-butyloxycarbonylaminomethyl-5-(3'-hydroxyphenylmethyl)nitrobenzene
CAS No.:375793-02-5
Molecular Formula:C₁₉H₂₂N₂O₅
Molecular Weight:358.394
Hs Code.:

Synonyms:2-tert-butyloxycarbonylaminomethyl-5-(3'-hydroxyphenylmethyl)nitrobenzene

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Chemical Property of 2-tert-butyloxycarbonylaminomethyl-5-(3'-hydroxyphenylmethyl)nitrobenzene

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Technology Process of 2-tert-butyloxycarbonylaminomethyl-5-(3'-hydroxyphenylmethyl)nitrobenzene

There total 9 articles about 2-tert-butyloxycarbonylaminomethyl-5-(3'-hydroxyphenylmethyl)nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 375792-83-9
2-tert-butyloxycarbonylaminomethyl-5-(3'-acetoxyphenylmethyl)-nitrobenzene

: 375793-02-5
2-tert-butyloxycarbonylaminomethyl-5-(3'-hydroxyphenylmethyl)nitrobenzene

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃;
DOI:10.1002/1521-3773(20010903)40:17<3148::AID-ANIE3148>3.0.CO;2-S

Reference yield:

: 49617-80-3
m-(bromomethyl)phenyl acetate

: 375793-02-5
2-tert-butyloxycarbonylaminomethyl-5-(3'-hydroxyphenylmethyl)nitrobenzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: Zn; 1,2-dibromoethane / tetrahydrofuran / 1 h / 20 °C

1.2: 58 percent / DIBAL-H / bis(triphenylphosphanyl)palladium(III) chloride / tetrahydrofuran; hexane / 20 °C

2.1: 94 percent / K₂CO₃ / methanol / 0.25 h

With potassium carbonate; ethylene dibromide; zinc; In tetrahydrofuran; methanol; 1.2: Negishi coupling reaction;
DOI:10.1002/1521-3765(20020315)8:6<1485::AID-CHEM1485>3.0.CO;2-H

Reference yield:

: 122-46-3
3-acetoxytoluene

: 375793-02-5
2-tert-butyloxycarbonylaminomethyl-5-(3'-hydroxyphenylmethyl)nitrobenzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 47 percent / NBS / CCl₄

2.1: Zn; 1,2-dibromoethane / tetrahydrofuran / 1 h / 20 °C

2.2: 58 percent / DIBAL-H / bis(triphenylphosphanyl)palladium(III) chloride / tetrahydrofuran; hexane / 20 °C

3.1: 94 percent / K₂CO₃ / methanol / 0.25 h

With N-Bromosuccinimide; potassium carbonate; ethylene dibromide; zinc; In tetrahydrofuran; methanol; tetrachloromethane; 2.2: Negishi coupling reaction;
DOI:10.1002/1521-3765(20020315)8:6<1485::AID-CHEM1485>3.0.CO;2-H