2-methoxyethanesulfonic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide

Base Information

Chemical Name:2-methoxyethanesulfonic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide
CAS No.:1613639-67-0
Molecular Formula:C₁₆H₂₀BrN₃O₃S
Molecular Weight:414.323
Hs Code.:

Synonyms:2-methoxyethanesulfonic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide

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Chemical Property of 2-methoxyethanesulfonic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide

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Technology Process of 2-methoxyethanesulfonic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide

There total 5 articles about 2-methoxyethanesulfonic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51517-01-2
2-methoxyethane-1-sulfonyl chloride

: 1613639-55-6
(R)-N-(5-bromopyridin-3-yl)-1-phenylethane-1,2-diamine

: 1613639-67-0
2-methoxyethanesulfonic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 875-74-1
(R)-phenylglycine

: 1613639-67-0
2-methoxyethanesulfonic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide

Guidance literature:: Multi-step reaction with 4 steps

1: L-proline; potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: hydrazine hydrate / ethanol / 1 h / 80 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; L-proline; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; 2: |Mitsunobu Displacement;

Reference yield:

: 625-92-3
3,5-dibromopyridine

: 1613639-67-0
2-methoxyethanesulfonic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide

Guidance literature:: Multi-step reaction with 4 steps

1: L-proline; potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: hydrazine hydrate / ethanol / 1 h / 80 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; L-proline; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; 2: |Mitsunobu Displacement;