51517-01-2

Basic information

• Product Name: 2-Methoxy-1-ethanesulfonyl Chloride
• Synonyms: 2-Methoxy-1-ethanesulfonyl Chloride;2-Methoxyethane-1-sulfonyl chloride;2-Methoxyethanesulfonyl chloride;2-Methoxyethylsulfonyl chloride
• CAS NO: 51517-01-2
• Molecular Formula: C₃H₇ClO₃S
• Molecular Weight: 158.60388
• Mol File: 51517-01-2.mol

Chemical Properties

• Boiling Point: 192℃
• Flash Point: 70℃
• Appearance: /
• Density: 1.357
• Vapor Pressure: 0.71mmHg at 25°C
• Refractive Index: 1.449
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-Methoxy-1-ethanesulfonyl Chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxy-1-ethanesulfonyl Chloride(51517-01-2)
• EPA Substance Registry System: 2-Methoxy-1-ethanesulfonyl Chloride(51517-01-2)

Safety Data

• Hazardous Substances Data: 51517-01-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxy-1-ethanesulfonyl Chloride is used as a reagent for the modification of biomolecules and chemical synthesis, particularly in the fields of pharmaceuticals. It is employed for the selective reaction with amino groups in peptides and proteins, which is crucial for the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
2-Methoxy-1-ethanesulfonyl Chloride is used as a reagent in the synthesis of agrochemicals. Its unique properties and reactivity contribute to the development of effective and targeted agrochemical products.
Used in Material Science:
2-Methoxy-1-ethanesulfonyl Chloride is used as a reagent in the synthesis of specialty chemicals and materials. Its versatility and reactivity enable the creation of novel materials with specific properties for various applications in material science.
Used in Chemical Research:
2-Methoxy-1-ethanesulfonyl Chloride is used as a valuable tool in chemical and biochemical research. Its ability to selectively react with amino groups in peptides and proteins allows for the exploration of new chemical reactions and the development of innovative synthetic methods.

InChI:InChI=1/C3H7ClO3S/c1-7-2-3-8(4,5)6/h2-3H2,1H3

Upstream product

• 6608-47-5 vinylsulfonyl chloride 
• 124-41-4 sodium methylate 
• 109-86-4 2-methoxy-ethanol 
• 6482-24-2 2-Bromoethyl methyl ether 
• 17356-08-0 thiourea 
• 627-42-9 2-chloroethyl methyl ether 
• 77281-03-9 sodium 2-methoxyethanesulfonate 
• 23022-96-0 2-ethansulfonsaeure-ethylester 

Downstream Products

• 51517-04-5 2-methoxyethane-1-sulfonamide 
• 1613639-67-0 2-methoxyethanesulfonic acid [(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]amide 
• 1375988-39-8 C₁₂H₁₈FNO₃S 
• 1376324-12-7 C₁₂H₁₆BrNO₃S 
• 1376375-04-0 2-methoxyethanesulfonic acid (1-phenylcyclobutyl)amide 
• 1376352-76-9 C₁₃H₁₉NO₃S 
• 1376316-95-8 C₁₃H₂₁NO₃S 
• 1376394-75-0 C₁₆H₁₉NO₄S 
• 1376327-21-7 C₁₂H₁₉NO₄S 
• 1376223-93-6 C₁₃H₂₁NO₃S 
• 1375976-45-6 C₁₀H₂₁NO₃S 
• 1366133-39-2 C₂₁H₃₄N₂O₃S 
• 1295574-97-8 N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-methoxyethanesulfonamide 
• 205194-05-4 4-(4-chloro-2-fluoroanilino)-7-(2-([N-methyl-N-(2-methoxyethylsulphonyl)]amino)ethoxy)6-methoxyquinazoline hydrochloride 

Relevant articles and documents

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THIAZOLIDINONE COMPOUNDS AND USE THEREOF

A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.

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Inhibitor for dipeptidyl peptidase-IV

The invention provides an aminotetrahydropyran derivative with a general formula (I) as described in the specification, pharmaceutically acceptable salts, hydrates, solvates and stereoisomers thereof, a preparation method for the aminotetrahydropyran derivative, and a pharmaceutical composition containing the aminotetrahydropyran derivative. The aminotetrahydropyran derivative provided by the invention can inhibit the activity of dipeptidyl peptidase-IV(DPP-IV), and can be used for treatment of diseases related to dipeptidyl peptidase-IV, especially for treatment of diabetes.

Aminotetrahydropyran derivative used as dipeptidyl peptidase-IV inhibitor

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NITROGENATED HETEROCYCLIC COMPOUND

A nitrogen-containing heterocyclic compound represented by formula (I-A): (wherein R1A represents lower alkyl which may be substituted with lower alkoxy, R3A represents lower alkyl substituted with fluorine atom(s), and RqA represents an optionally substituted aromatic heterocyclic group) or the like, or a pharmaceutically acceptable salt thereof; and the like, are provided.

Clean and economic synthesis of alkanesulfonyl chlorides from S-alkyl isothiourea salts via bleach oxidative chlorosulfonation

A simple procedure for clean and economic synthesis of alkanesulfonyl chlorides via bleach-mediated oxidative chlorosulfonation of S-alkyl isothiourea salts is disclosed. This procedure is environment- and worker-friendly with the advantages of readily accessible materials and reagents, simple and safe operations, easy purification without chromatography, and affords high yields of up to 99%.

NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING INHIBITORY EFFECT ON PRODUCTION OF KYNURENINE

The present invention provides a nitrogen-containing heterocyclic compound or a pharmaceutically acceptable salt thereof having an inhibitory effect on the production of kynurenine, represented by formula (I): (wherein R6 and R7 may be the same or different and each represent a hydrogen atom or the like, R8, R9, R19, and R11 may be the same or different and each represent a hydrogen atom or the like, R1 represents lower alkyl which may be substituted with cycloalkyl, or the like, and R3 represents optionally substituted aryl or an optionally substituted heterocyclic group).

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