1-(3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-5-fluorouracil

Base Information

Chemical Name:1-(3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-5-fluorouracil
CAS No.:306305-16-8
Molecular Formula:C₃₁H₃₇FN₂O₆Si
Molecular Weight:580.728
Hs Code.:

Synonyms:1-(3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-5-fluorouracil

Suppliers and Price of 1-(3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-5-fluorouracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-5-fluorouracil

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 1-(3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-5-fluorouracil

There total 2 articles about 1-(3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-5-fluorouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.4%

: 306305-15-7
1-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-5-fluorouracil

: 306305-16-8
1-(3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-5-fluorouracil

Guidance literature:: With methanol; triethylamine; at 30 ℃; for 48h;
DOI:10.1021/jm000209n

Reference yield:

: 233266-82-5
1,2-di-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-D-ribo-pentofuranose

: 306305-16-8
1-(3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-5-fluorouracil

Guidance literature:: Multi-step reaction with 2 steps

1: 35.4 percent / N,O-bis(trimethylsilyl)acetamide; trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 1 h / Heating

2: 94.4 percent / triethylamine; methanol / 48 h / 30 °C

With methanol; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; triethylamine; In 1,2-dichloro-ethane;
DOI:10.1021/jm000209n