233266-82-5

Upstream product

• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 
• 233266-80-3 (((3aR,5R,6S,6aR)-6-(benzyloxy)-5-((benzyloxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethynyl)triethylsilane 
• 233266-77-8 3,5-di-O-benzyl-4-C-(2,2-dibromoethenyl)-1,2-O-isopropylidene-α-D-ribo-pentofuranose 
• 233266-78-9 3,5-di-O-benzyl-4-C-ethynyl-1,2-O-isopropylidene-D-ribo-pentofuranose 
• 233266-76-7 (3aR,5R,6S,6aR)-6-(benzyloxy)-5-((benzyloxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde 
• 153186-10-8 ((3aR,5R,6S,6aR)-6-(benzyloxy)-5-((benzyloxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol 
• 108-24-7 acetic anhydride 

Downstream Products

• 233266-86-9 (2R,3R,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-5-((triethylsilyl)ethynyl)tetrahydrofuran-3-yl acetate 
• 233266-85-8 (2R,3R,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-5-((triethylsilyl)ethynyl)tetrahydrofuran-3-yl acetate 
• 306305-15-7 1-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-5-fluorouracil 
• 306305-04-4 9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine 
• 865363-93-5 (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol monohydrate 
• 1055039-87-6 thiocarbonic acid O-[4-benzyloxy-5-benzyloxymethyl-2-(2,6-diamino-purin-9-yl)-5-triethylsilanylethynyl-tetrahydro-furan-3-yl] ester O-phenyl ester 
• 1053714-14-9 thiocarbonic acid O-[2-(6-amino-purin-9-yl)-4-benzyloxy-5-benzyloxymethyl-5-triethylsilanylethynyl-tetrahydro-furan-3-yl] ester O-phenyl ester 
• 306305-10-2 9-(3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine 
• 306305-11-3 9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine 
• 306305-16-8 1-(3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-5-fluorouracil 
• 311348-86-4 1-(3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-5-ethyluracil 
• 306305-05-5 9-(3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine 
• 306305-06-6 9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine 
• 1054625-37-4 9-((2R,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-5-ethynyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine 

Relevant academic research and scientific papers

Synthesis of EFdA via a diastereoselective aldol reaction of a protected 3-keto furanose

An efficient enantioselective total synthesis of EFdA, a remarkably potent anti-HIV nucleoside analogue with various favorable pharmacological profiles, has been achieved in 37% overall yield from diacetone-d-glucose by a 14-step sequence that features a

4′-C-ethynyl pyrimidine nucleoside compounds and pharmaceutical compositions

The invention provides 4′-C-ethynyl pyrimidine nucleosides (other than 4′-C-ethynylthymidine) represented by formula [I]: wherein B represents a base selected from the group consisting of pyrimidine and derivatives thereof; X represents a hydrogen atom or

Synthesis of 4'-C-ethynyl-beta-D-arabino- and 4'-C-ethynyl-2'-deoxy-beta- D-ribo-pentofuranosyl pyrimidines, and their biological evaluation.

4'-C-Ethynyl-beta-D-arabino-pentofuranosyl thymine (14) and cytosine (16), and 4'-C-ethynyl-2'-deoxy-beta-D-ribo-pentofuranosyl thymine (25) and cytosine (27) were synthesized by properly protected 4'-C-hydroxy-methyl-3,5-di-O-benzyl-alpha-D-ribo-pentofur