tert-butyl {4-{benzyl[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]amino}butyl}carbamate

Base Information

Chemical Name:tert-butyl {4-{benzyl[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]amino}butyl}carbamate
CAS No.:201211-59-8
Molecular Formula:C₂₇H₃₅N₃O₄
Molecular Weight:465.593
Hs Code.:

Synonyms:tert-butyl {4-{benzyl[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]amino}butyl}carbamate

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Chemical Property of tert-butyl {4-{benzyl[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]amino}butyl}carbamate

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Technology Process of tert-butyl {4-{benzyl[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]amino}butyl}carbamate

There total 7 articles about tert-butyl {4-{benzyl[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]amino}butyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 5460-29-7
2-(3-bromopropyl)isoindole-1,3-dione

: 90914-09-3
N⁽¹⁾-benzyl-N⁽⁴⁾-(tert-butyloxycarbonyl)-1,4-diaminobutane

: 201211-59-8
tert-butyl {4-{benzyl[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]amino}butyl}carbamate

Guidance literature:: With sodium carbonate; In chloroform; acetonitrile; at 75 ℃; for 72h;
DOI:10.1039/c0jm04064a

Reference yield:

: 68076-36-8
1-amino-4-[(tert-butyloxycarbonyl)amino]butane

: 201211-59-8
tert-butyl {4-{benzyl[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]amino}butyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 0.75 h / 23 °C

1.2: 95 percent / NaBH₄ / methanol / 17 h / 23 °C

2.1: 78 percent / K₂CO₃ / acetonitrile / 23 h / 70 °C

With potassium carbonate; In methanol; acetonitrile;
DOI:10.1002/hlca.200490129

Reference yield:

: 100-52-7
benzaldehyde

: 201211-59-8
tert-butyl {4-{benzyl[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]amino}butyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) formic acid, 2.) 6M HCl / 1.) 0 deg C -> reflux (2 h), reflux, overnight, 2.) reflux, 20 h

2: 82 percent / NaOH / dioxane / 3 h

3: 62 percent / KI, Na₂CO₃ / butan-1-ol / 51 h / 50 °C

With hydrogenchloride; sodium hydroxide; formic acid; sodium carbonate; potassium iodide; In 1,4-dioxane; butan-1-ol;
DOI:10.1016/S0040-4020(97)10156-9