(R)-t-butyl 4-((2-(t-butylamino)-1-phenylethyl)amino)piperidine-1-carboxylate

Base Information

Chemical Name:(R)-t-butyl 4-((2-(t-butylamino)-1-phenylethyl)amino)piperidine-1-carboxylate
CAS No.:926293-49-4
Molecular Formula:C₂₂H₃₇N₃O₂
Molecular Weight:375.555
Hs Code.:

Synonyms:(R)-t-butyl 4-((2-(t-butylamino)-1-phenylethyl)amino)piperidine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-t-butyl 4-((2-(t-butylamino)-1-phenylethyl)amino)piperidine-1-carboxylate

Chemical Property:

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Technology Process of (R)-t-butyl 4-((2-(t-butylamino)-1-phenylethyl)amino)piperidine-1-carboxylate

There total 6 articles about (R)-t-butyl 4-((2-(t-butylamino)-1-phenylethyl)amino)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 926293-49-4
(R)-t-butyl 4-((2-(t-butylamino)-1-phenylethyl)amino)piperidine-1-carboxylate

Guidance literature:

Reference yield:

: 926293-48-3
(R)-N¹-(tert-butyl)-1-phenylethane-1,2-diamine

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 926293-49-4
(R)-t-butyl 4-((2-(t-butylamino)-1-phenylethyl)amino)piperidine-1-carboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm401101p

Reference yield:

: 33125-05-2
Boc-D-Phg-OH

: 926293-49-4
(R)-t-butyl 4-((2-(t-butylamino)-1-phenylethyl)amino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

3: borane-THF / 18 h / 60 °C / Inert atmosphere

4: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 20 °C / Inert atmosphere

With 4-methyl-morpholine; borane-THF; sodium tris(acetoxy)borohydride; acetic acid; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm401101p