4-(4-fluoro-2-isopropoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(4-fluoro-2-isopropoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:910605-65-1
Molecular Formula:C₁₉H₂₈FNO₃
Molecular Weight:337.435
Hs Code.:

Synonyms:4-(4-fluoro-2-isopropoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-(4-fluoro-2-isopropoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-(4-fluoro-2-isopropoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

There total 5 articles about 4-(4-fluoro-2-isopropoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 946605-67-0
C₁₉H₂₆FNO₃

: 910605-65-1
4-(4-fluoro-2-isopropoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; acetic acid; 10 wt% platinum on carbon; In ethanol; at 20 ℃; for 18h; under 2585.81 Torr;

Reference yield:

: 910605-64-0
4-(4-fluoro-2-isopropoxy-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

: 910605-65-1
4-(4-fluoro-2-isopropoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / MsCl; Et₃N / CH₂Cl₂ / 12 h / -78 °C

2: 80 percent / H₂ / Pd/C / 8 h / 20 °C / 2327.23 Torr

With hydrogen; methanesulfonyl chloride; triethylamine; palladium on activated charcoal; In dichloromethane;
DOI:10.1016/j.bmcl.2007.04.098

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 910605-65-1
4-(4-fluoro-2-isopropoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: nBuLi / tetrahydrofuran / 1 h / -78 °C

1.2: tetrahydrofuran

2.1: 50 percent / MsCl; Et₃N / CH₂Cl₂ / 12 h / -78 °C

3.1: 80 percent / H₂ / Pd/C / 8 h / 20 °C / 2327.23 Torr

With n-butyllithium; hydrogen; methanesulfonyl chloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2007.04.098