4-(4-fluoro-2-isopropoxy-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(4-fluoro-2-isopropoxy-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:910605-64-0
Molecular Formula:C₁₉H₂₈FNO₄
Molecular Weight:353.434
Hs Code.:

Synonyms:4-(4-fluoro-2-isopropoxy-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-(4-fluoro-2-isopropoxy-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-(4-fluoro-2-isopropoxy-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

There total 2 articles about 4-(4-fluoro-2-isopropoxy-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 610797-49-4
1-bromo-4-fluoro-2-isopropoxybenzene

: 910605-64-0
4-(4-fluoro-2-isopropoxy-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: N-tert-butyloxycarbonylpiperidin-4-one; 1-bromo-4-fluoro-2-isopropoxybenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 5.25h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield:

: 147460-41-1
2-bromo-5-fluorophenol

: 910605-64-0
4-(4-fluoro-2-isopropoxy-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 8 h / 20 °C

2.1: nBuLi / tetrahydrofuran / 1 h / -78 °C

2.2: tetrahydrofuran

With n-butyllithium; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.04.098

Reference yield:

: 910605-64-0
4-(4-fluoro-2-isopropoxy-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

: 910605-68-4
4-[4-(4-fluoro-2-isopropoxy-phenyl)-piperidin-1-yl]-cyclohexylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / MsCl; Et₃N / CH₂Cl₂ / 12 h / -78 °C

2: 80 percent / H₂ / Pd/C / 8 h / 20 °C / 2327.23 Torr

3: 100 percent / TFA / CH₂Cl₂ / 3 h / 0 °C

4: NaBH(OAc)3; AcOH / CH₂Cl₂ / 8 h / 20 °C

5: CF₃CO₂H / CH₂Cl₂ / 2 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane;
DOI:10.1016/j.bmcl.2007.04.098