3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionic acid

Base Information

• Chemical Name: 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionic acid
• CAS No.: 1346017-95-5
• Molecular Formula: C₁₇H₂₂F₃NO₅
• Molecular Weight: 377.361
• Mol file: 1346017-95-5.mol

Synonyms:3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionic acid

Chemical Property of 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionic acid

There total 8 articles about 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionate (1346017-94-4) → 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionic acid (1346017-95-5)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield:

4-Trifluoromethoxyphenol (828-27-3) → 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionic acid (1346017-95-5)

Guidance literature:

Multi-step reaction with 5 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; water / 20 °C

2: trifluoroacetic acid; water / 3 h / 20 °C

3: 0.83 h / 0 °C

4: potassium carbonate / acetonitrile / 3 h / Reflux

5: water; sodium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C

With di-isopropyl azodicarboxylate; water; potassium carbonate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; water; acetonitrile;

Reference yield:

2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethanol (1346017-80-8) → 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionic acid (1346017-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 3 h / Reflux

2: water; sodium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C

With water; potassium carbonate; sodium hydroxide; In tetrahydrofuran; acetonitrile;

upstream raw materials:

2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethanol

ethyl 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionate

tert-butyl 4-(4-(trifluoromethoxy)phenoxy)piperidin-1-carboxylate

4-(4-(trifluoromethoxy)phenoxy)piperidine

Downstream raw materials:

3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionyl chloride