ethyl 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionate

Base Information

• Chemical Name: ethyl 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionate
• CAS No.: 1346017-94-4
• Molecular Formula: C₁₉H₂₆F₃NO₅
• Molecular Weight: 405.414
• Mol file: 1346017-94-4.mol

Synonyms:ethyl 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionate

Chemical Property of ethyl 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionate

There total 7 articles about ethyl 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

Ethyl 3-bromopropionate (539-74-2) + 2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethanol (1346017-80-8) → ethyl 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionate (1346017-94-4)

Guidance literature:

With potassium carbonate; In acetonitrile; for 3h; Reflux;

Reference yield:

4-Trifluoromethoxyphenol (828-27-3) → ethyl 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionate (1346017-94-4)

Guidance literature:

Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; water / 20 °C

2: trifluoroacetic acid; water / 3 h / 20 °C

3: 0.83 h / 0 °C

4: potassium carbonate / acetonitrile / 3 h / Reflux

With di-isopropyl azodicarboxylate; water; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; water; acetonitrile;

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → ethyl 3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionate (1346017-94-4)

Guidance literature:

Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; water / 20 °C

2: trifluoroacetic acid; water / 3 h / 20 °C

3: 0.83 h / 0 °C

4: potassium carbonate / acetonitrile / 3 h / Reflux

With di-isopropyl azodicarboxylate; water; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; water; acetonitrile;

upstream raw materials:

Ethyl 3-bromopropionate

2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethanol

tert-butyl 4-(4-(trifluoromethoxy)phenoxy)piperidin-1-carboxylate

4-(4-(trifluoromethoxy)phenoxy)piperidine

Downstream raw materials:

3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionyl chloride

3-(2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)ethoxy)propionic acid