1,1-dimethylethyl (S)-3-bromo-5-chloro-2-[(2-methoxyethoxy)methoxy]-β-[[(1S)-2-hydroxy-1-phenylethyl]amino]benzenepropanoate

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Chemical Name:1,1-dimethylethyl (S)-3-bromo-5-chloro-2-[(2-methoxyethoxy)methoxy]-β-[[(1S)-2-hydroxy-1-phenylethyl]amino]benzenepropanoate
CAS No.:240424-50-4
Molecular Formula:C₂₅H₃₃BrClNO₆
Molecular Weight:558.897
Hs Code.:

Synonyms:1,1-dimethylethyl (S)-3-bromo-5-chloro-2-[(2-methoxyethoxy)methoxy]-β-[[(1S)-2-hydroxy-1-phenylethyl]amino]benzenepropanoate

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Chemical Property of 1,1-dimethylethyl (S)-3-bromo-5-chloro-2-[(2-methoxyethoxy)methoxy]-β-[[(1S)-2-hydroxy-1-phenylethyl]amino]benzenepropanoate

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Technology Process of 1,1-dimethylethyl (S)-3-bromo-5-chloro-2-[(2-methoxyethoxy)methoxy]-β-[[(1S)-2-hydroxy-1-phenylethyl]amino]benzenepropanoate

There total 5 articles about 1,1-dimethylethyl (S)-3-bromo-5-chloro-2-[(2-methoxyethoxy)methoxy]-β-[[(1S)-2-hydroxy-1-phenylethyl]amino]benzenepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: β-(S)-β-[(E)-[[3-]methyl-ene]amino]phenylethanol

: 5292-43-3
bromoacetic acid tert-butyl ester

: 240424-50-4
1,1-dimethylethyl (S)-3-bromo-5-chloro-2-[(2-methoxyethoxy)methoxy]-β-[[(1S)-2-hydroxy-1-phenylethyl]amino]benzenepropanoate

Guidance literature:: bromoacetic acid tert-butyl ester; With zinc; In tetrahydrofuran; at 50 ℃; for 1h;

β-(S)-β-[(E)-[[3-]methyl-ene]amino]phenylethanol; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at -8 ℃; for 3h;
DOI:10.1021/jo050177h

Reference yield:

: 240424-48-0
3-bromo-5-chloro-2-[(2-methoxyethoxy)methoxy]benzaldehyde

: 240424-50-4
1,1-dimethylethyl (S)-3-bromo-5-chloro-2-[(2-methoxyethoxy)methoxy]-β-[[(1S)-2-hydroxy-1-phenylethyl]amino]benzenepropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: MgSO₄ / toluene / 2 h / 22 °C

2.1: Zn metal / tetrahydrofuran / 1 h / 50 °C

2.2: 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 3 h / -8 °C

With magnesium sulfate; zinc; In tetrahydrofuran; toluene; 2.2: Reformatsky coupling;
DOI:10.1021/jo050177h

Reference yield:

: 19652-32-5
3-bromo-5-chlorosalicylaldehyde

: 240424-50-4
1,1-dimethylethyl (S)-3-bromo-5-chloro-2-[(2-methoxyethoxy)methoxy]-β-[[(1S)-2-hydroxy-1-phenylethyl]amino]benzenepropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 88 percent / K₂CO₃ / dimethylformamide / 3 h / 22 °C

2.1: MgSO₄ / toluene / 2 h / 22 °C

3.1: Zn metal / tetrahydrofuran / 1 h / 50 °C

3.2: 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 3 h / -8 °C

With magnesium sulfate; potassium carbonate; zinc; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 3.2: Reformatsky coupling;
DOI:10.1021/jo050177h