10.1080/24701556.2021.1917611
The research focuses on the synthesis, crystal structure, and antibacterial activity of three new complexes: two copper(II) complexes, [Cu(L1)2] (1) and [CuL2(N3)] (2), and one cadmium(II) complex, [Cd(L3)2] (3). The ligands L1, L2, and L3 are derived from 3-bromo-5-chlorosalicylaldehyde and different amines, resulting in N,O- or N,N,O-donor monocondensed Schiff bases. The synthesis involved reactions in ethanol, with the addition of NaBH4 and metal salts like Cu(ClO4)2·6H2O and Cd(CH3COO)2·2H2O. Characterization included IR, UV-Vis, and elemental analysis, with crystal structures determined by X-ray crystallography. Antibacterial assays were conducted on Gram-positive (B. subtilis, S. aureus) and Gram-negative (E. coli, P. aeruginosa) bacteria using the MTT method to determine IC50 values. The complexes showed promising antibacterial activities, with complex 1 being particularly effective against S. aureus, surpassing the activity of Penicillin G.
10.1134/S0022476612030286
The research focuses on the synthesis and crystal structure analysis of a new copper(II) complex, bis[2-((E)-(p-tolylimino)methyl)-6-bromo-4-chlorophenol]copper(II). The key chemicals involved in this research include 3-bromo-5-chloro-2-hydroxybenzaldehyde, p-toluidine, and CuCl??2H?O. These chemicals were used in the synthesis process, where the reaction of 3-bromo-5-chloro-2-hydroxybenzaldehyde with p-toluidine followed by the addition of CuCl??2H?O resulted in the formation of the complex. The synthesized complex was then characterized using single crystal X-ray diffraction analysis, revealing its crystal structure and coordination geometry. The complex crystallizes in the monoclinic system with a P21/c space group and exhibits a coordination geometry around copper(II) that is intermediate between square planar and tetrahedral. The structure is stabilized by weak intermolecular Br…Br interactions and Cu…Cl contacts, forming one-dimensional chains and two-dimensional layers.