N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylphenylalanylleucine

Base Information

Chemical Name:N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylphenylalanylleucine
CAS No.:109335-03-7
Molecular Formula:C₄₆H₅₇N₅O₇
Molecular Weight:791.988
Hs Code.:

Synonyms:N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylphenylalanylleucine

Suppliers and Price of N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylphenylalanylleucine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylphenylalanylleucine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylphenylalanylleucine

There total 10 articles about N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylphenylalanylleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.2%

: 109335-06-0
N,N-dibenzyl-O-tert-butyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylphenylalanylleucine tert-butyl ester

: 109335-03-7
N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylphenylalanylleucine

Guidance literature:: With methoxybenzene; trifluoroacetic acid; In dichloromethane; at 0 - 25 ℃; for 0.0375h;
DOI:10.1021/jm00392a025

Reference yield:

: 6671-25-6
2-(2-benzyloxycarbonylamino-2-methyl-propionylamino)-2-methylpropionic acid methyl ester

: 109335-03-7
N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylphenylalanylleucine

Guidance literature:: Multi-step reaction with 8 steps

1: 87.2 percent / H₂, conc. HCl / 10percent Pd/C / methanol / 0.75 h / 760 Torr

2: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 1.) -15 deg C, 45 min, 2.) 25 deg C, 2.5 h

3: 73.8 percent / ammonium formate / 10percent Pd/C / methanol / 0.25 h / 25 °C

4: 84.3 percent / N,N-diisopropylethylamine / acetonitrile / 18 h / 25 °C

5: 94.9 percent / 4N NaOH / methanol; tetrahydrofuran / 18 h / 25 °C

6: Et₃N / toluene / 4.5 h / -5 - 25 °C

7: toluene / 48 h / 25 °C

8: 90.2 percent / TFA, anisole / CH₂Cl₂ / 0.04 h / 0 - 25 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; ammonium formate; methoxybenzene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm00392a025

Reference yield:

: 5545-54-0
N-(benzyloxycarbonyl)-O-(1,1-dimethylethyl)-L-tyrosine

: 109335-03-7
N,N-dibenzyltyrosyl-α-aminoisobutyryl-α-aminoisobutyrylphenylalanylleucine

Guidance literature:: Multi-step reaction with 8 steps

1: N-methylmorpholine / tetrahydrofuran / 0.03 h / -18 - -12 °C

2: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 1.) -15 deg C, 45 min, 2.) 25 deg C, 2.5 h

3: 73.8 percent / ammonium formate / 10percent Pd/C / methanol / 0.25 h / 25 °C

4: 84.3 percent / N,N-diisopropylethylamine / acetonitrile / 18 h / 25 °C

5: 94.9 percent / 4N NaOH / methanol; tetrahydrofuran / 18 h / 25 °C

6: Et₃N / toluene / 4.5 h / -5 - 25 °C

7: toluene / 48 h / 25 °C

8: 90.2 percent / TFA, anisole / CH₂Cl₂ / 0.04 h / 0 - 25 °C

With 4-methyl-morpholine; sodium hydroxide; ammonium formate; methoxybenzene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm00392a025