2-{2-[2-fluoro-5-(methyloxy)phenyl]-1H-imidazol-4-yl}-N-methyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide

Base Information

Chemical Name:2-{2-[2-fluoro-5-(methyloxy)phenyl]-1H-imidazol-4-yl}-N-methyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide
CAS No.:1338344-88-9
Molecular Formula:C₂₂H₂₂FN₅O₃
Molecular Weight:423.447
Hs Code.:

Synonyms:2-{2-[2-fluoro-5-(methyloxy)phenyl]-1H-imidazol-4-yl}-N-methyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide

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Chemical Property of 2-{2-[2-fluoro-5-(methyloxy)phenyl]-1H-imidazol-4-yl}-N-methyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide

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Technology Process of 2-{2-[2-fluoro-5-(methyloxy)phenyl]-1H-imidazol-4-yl}-N-methyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide

There total 4 articles about 2-{2-[2-fluoro-5-(methyloxy)phenyl]-1H-imidazol-4-yl}-N-methyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1338346-15-8
2-[2-fluoro-5-(methyloxy)phenyl]-1H-imidazole-4-carbaldehyde

: 1353715-48-6
3-amino-N-methyl-4-{[2-(methyloxy)ethyl]amino}benzamide

: 1338344-88-9
2-{2-[2-fluoro-5-(methyloxy)phenyl]-1H-imidazol-4-yl}-N-methyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide

Guidance literature:: With sodium hydrogensulfite; In ethanol; water; at 150 ℃; for 0.0833333h; Microwave irradiation;

Reference yield:

: 127667-01-0
2-fluoro 5-methoxybenzonitrile

: 1338344-88-9
2-{2-[2-fluoro-5-(methyloxy)phenyl]-1H-imidazol-4-yl}-N-methyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C / Inert atmosphere

1.2: 20 °C / Cooling with ice

2.1: ammonium hydroxide; ammonium chloride / water / 1.5 h / 80 °C

3.1: manganese(IV) oxide / chloroform / 4 h / 80 °C / Inert atmosphere

4.1: sodium hydrogensulfite / ethanol; water / 0.08 h / 150 °C / Microwave irradiation

With manganese(IV) oxide; ammonium hydroxide; ammonium chloride; sodium hydrogensulfite; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; chloroform; water;

Reference yield:

: 152335-99-4
2-fluoro-5-(methyloxy)benzenecarboximidamide

: 1338344-88-9
2-{2-[2-fluoro-5-(methyloxy)phenyl]-1H-imidazol-4-yl}-N-methyl-1-[2-(methyloxy)ethyl]-1H-benzimidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium hydroxide; ammonium chloride / water / 1.5 h / 80 °C

2: manganese(IV) oxide / chloroform / 4 h / 80 °C / Inert atmosphere

3: sodium hydrogensulfite / ethanol; water / 0.08 h / 150 °C / Microwave irradiation

With manganese(IV) oxide; ammonium hydroxide; ammonium chloride; sodium hydrogensulfite; In ethanol; chloroform; water;