tert-butyl 1-(4-(3-(4-carbamoylphenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-ylcarbamate

Base Information

Chemical Name:tert-butyl 1-(4-(3-(4-carbamoylphenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-ylcarbamate
CAS No.:1464153-53-4
Molecular Formula:C₃₀H₃₂N₆O₄
Molecular Weight:540.622
Hs Code.:

Synonyms:tert-butyl 1-(4-(3-(4-carbamoylphenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-ylcarbamate

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Chemical Property of tert-butyl 1-(4-(3-(4-carbamoylphenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-ylcarbamate

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Technology Process of tert-butyl 1-(4-(3-(4-carbamoylphenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-ylcarbamate

There total 6 articles about tert-butyl 1-(4-(3-(4-carbamoylphenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1464153-51-2
ethyl 4-(3-(4-carbamoylphenyl)imidazo[1,2-a]pyrazin-6-yl)benzoate

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1464153-53-4
tert-butyl 1-(4-(3-(4-carbamoylphenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-ylcarbamate

Guidance literature:: With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 10h; Inert atmosphere;

Reference yield:

: 1464153-52-3
ethyl 4-(3-(4-carbamoylphenyl)imidazo[1,2-a]pyrazin-6-yl)benzoate

: 1464153-53-4
tert-butyl 1-(4-(3-(4-carbamoylphenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / methanol; tetrahydrofuran / 5 h / 20 °C

2: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 10 h / Inert atmosphere

With 4-methyl-morpholine; lithium hydroxide monohydrate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 123088-59-5
4-carbamoylphenylboronic acid

: 1464153-53-4
tert-butyl 1-(4-(3-(4-carbamoylphenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)piperidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 2 h / 90 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 16 h / 90 °C / Inert atmosphere

3: lithium hydroxide monohydrate / methanol; tetrahydrofuran / 5 h / 20 °C

4: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 10 h / Inert atmosphere

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; sodium carbonate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;