({6-[({6-[(Bis-carboxymethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-ethoxycarbonylmethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-carboxymethyl-amino)-acetic acid

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Chemical Name:({6-[({6-[(Bis-carboxymethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-ethoxycarbonylmethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-carboxymethyl-amino)-acetic acid
CAS No.:178321-79-4
Molecular Formula:C₄₂H₄₁N₅O₁₀
Molecular Weight:775.815
Hs Code.:

({6-[({6-[(Bis-carboxymethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-ethoxycarbonylmethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-carboxymethyl-amino)-acetic acid

Synonyms:({6-[({6-[(Bis-carboxymethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-ethoxycarbonylmethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-carboxymethyl-amino)-acetic acid

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Chemical Property of ({6-[({6-[(Bis-carboxymethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-ethoxycarbonylmethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-carboxymethyl-amino)-acetic acid

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Technology Process of ({6-[({6-[(Bis-carboxymethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-ethoxycarbonylmethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-carboxymethyl-amino)-acetic acid

There total 4 articles about ({6-[({6-[(Bis-carboxymethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-ethoxycarbonylmethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-carboxymethyl-amino)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 178321-77-2
(Bis-{6-[(bis-tert-butoxycarbonylmethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-amino)-acetic acid ethyl ester

: 178321-79-4
({6-[({6-[(Bis-carboxymethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-ethoxycarbonylmethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-carboxymethyl-amino)-acetic acid

Guidance literature:: With trifluoroacetic acid; for 1.5h; Ambient temperature;
DOI:10.1002/hlca.19960790321

Reference yield:

: 106967-42-4
4-bromo-2,6-bis(bromomethyl)pyridine

: 178321-79-4
({6-[({6-[(Bis-carboxymethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-ethoxycarbonylmethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-carboxymethyl-amino)-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 48 percent / K₂CO₃ / acetonitrile / 4 h / 50 °C

2: 54 percent / (i-Pr)2EtN / acetonitrile / 4 h / 45 - 50 °C

3: 76 percent / CuI / bis(triphenylphosphine)palladium(II) chloride / triethylamine; tetrahydrofuran / 18 h / 55 °C

4: 98 percent / CF₃COOH / 1.5 h / Ambient temperature

With copper(l) iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; bis(triphenylphosphine)palladium(II)-chloride; In tetrahydrofuran; triethylamine; acetonitrile;
DOI:10.1002/hlca.19960790321

Reference yield:

: 178321-70-5
4-bromo-6-bromomethyl-2-pyridylmethylenenitrilobis(acetic acid) di(tert-butyl ester)

: 178321-79-4
({6-[({6-[(Bis-carboxymethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-ethoxycarbonylmethyl-amino)-methyl]-4-phenylethynyl-pyridin-2-ylmethyl}-carboxymethyl-amino)-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / (i-Pr)2EtN / acetonitrile / 4 h / 45 - 50 °C

2: 76 percent / CuI / bis(triphenylphosphine)palladium(II) chloride / triethylamine; tetrahydrofuran / 18 h / 55 °C

3: 98 percent / CF₃COOH / 1.5 h / Ambient temperature

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; bis(triphenylphosphine)palladium(II)-chloride; In tetrahydrofuran; triethylamine; acetonitrile;
DOI:10.1002/hlca.19960790321