106967-42-4

Basic information

• Product Name: 2,6-Bis(bromomethyl)-4-bromopyridine
• Synonyms: 2,6-Bis(bromomethyl)-4-bromopyridine;4-Bromo-2,6-bis(bromomethyl)pyridine
• CAS NO: 106967-42-4
• Molecular Formula: C₇H₆Br₃N
• Molecular Weight: 343.843
• Mol File: 106967-42-4.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2,6-Bis(bromomethyl)-4-bromopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Bis(bromomethyl)-4-bromopyridine(106967-42-4)
• EPA Substance Registry System: 2,6-Bis(bromomethyl)-4-bromopyridine(106967-42-4)

Safety Data

• Hazardous Substances Data: 106967-42-4(Hazardous Substances Data)

Usage

General Description

2,6-Bis(bromomethyl)-4-bromopyridine is a chemical compound with the molecular formula C8H6Br3N. It is a derivative of pyridine, a heterocyclic compound commonly found in various pharmaceuticals and agrochemicals. 2,6-Bis(bromomethyl)-4-bromopyridine is a bromine-substituted derivative of 2,6-bis(chloromethyl)-4-chloropyridine, and it is commonly used in the synthesis of complex organic molecules, such as pharmaceuticals and other biologically active compounds. It can also be used as a building block in the preparation of various polymers and materials. 2,6-Bis(bromomethyl)-4-bromopyridine is typically handled and stored under controlled conditions due to its potential reactivity and toxicity.

Upstream product

• 120491-93-2 4-bromopyridine-2,6-dicarbonyl dibromide 
• 20443-03-2 4-oxo-1,4-dihydro-pyridine-2,6-dicarboxylic acid dimethyl ester 
• 99-32-1 chelidonic acid 
• 120491-91-0 2,6-bis(hydroxymethyl)-4-iodopyridine 
• 162102-79-6 dimethyl 4-bromo-2,6-pyridinedicarboxylate 
• 499-51-4 Chelidamic acid 
• 162102-81-0 4-bromopyridine-2,6-dicarboxylic acid 
• 138-60-3 chelidamic acid 
• 112776-83-7 diethyl 4-bromo-2,6-pyridinedicarboxylate 
• 120491-88-5 4-bromo-2,6-pyridinedimethanol 

Downstream Products

• 128184-05-4 13-bromo-3,6,9-tritosyl-3,6,9,15-tetraazabicyclo<9.3.1>pentadeca-1(15),11,13-triene 
• 106967-41-3 15-bromo-3,7,11-tritosyl-3,7,11,17-tetraazabicyclo<11.3.1>heptadeca-1(17),13,15-triene 
• 1361953-57-2 4-(4-phenyl-1H-1,2,3-triazol-1-yl)-2,6-bis((bis(carboxymethyl)amino)methyl)pyridine 
• 1609488-33-6 europium(III)-2,2'-(((6-(((carboxymethyl)(methyl)amino)methyl)-4-((4-(dimethylamino)phenyl)ethynyl)pyridin-2-yl)methyl)azanediyl)diacetic acid 
• 1609476-23-4 diethyl 2,2'-{[(4-{[4-(dimethylamino)phenyl]ethynyl}-6-{[(2-methoxy-2-oxoethyl)(methyl)amino]methyl}pyridin-2-yl)methyl]azanediyl}diacetate 
• 1446687-61-1 tetra-tert-butyl 2,2',2'',2''-(((((4-((4-aminophenyl)ethynyl)pyridine-2,6-diyl)bis(methylene))bis((2-(tert-butoxy)-2-oxoethyl)azanediyl))bis(ethane-2,1-diyl))bis(azanetriyl))-tetraacetate 
• 1446687-62-2 di-tert-butyl 2,2'-(((4-((4-aminophenyl)ethynyl)-6-(((2-(bis(2-(tert-butoxy)-2-oxoethyl)amino)-ethyl)(2-(tert-butoxy)-2-oxoethyl)amino)methyl)pyridin-2-yl)methyl)azanediyl)diacetate 
• 1444764-55-9 tetraethyl 2,2',2,2'-(((6,6'-(((4-aminophenethyl)azanediyl)bis(methylene))bis(4-bromopyridine-6,2-diyl))bis(methylene))bis(azanetriyl))tetraacetate 
• 1435951-12-4 2,6-bis((2-(4-(2-(allyloxy)ethoxy)phenoxy)ethoxy)methyl)-4-bromopyridine 
• 854923-84-5 2-dimethyl-4-bromo-6-bromomethyl-2-pyridylmethylimino-(diacetate) 
• 128184-08-7 (7,11-Bis-tert-butoxycarbonylmethyl-15-phenylethynyl-3,7,11,17-tetraaza-bicyclo[11.3.1]heptadeca-1⁽¹⁶⁾,13⁽¹⁷⁾,14-trien-3-yl)-acetic acid tert-butyl ester 
• 128184-02-1 15-(phenylethynyl)-3,7,11-tris(carboxymethyl)-3,7,11,17-tetraazabicyclo<11.3.1>heptadeca-1(17),13,15-triene 
• 128184-09-8 13-(phenylethynyl)-3,6,9-tris(carboxymethyl)-3,6,9,15-tetraazabicyclo<9.3.1>pentadeca-1(15),11,13-triene 
• 178321-78-3 tetra(tert-butyl) 2,2',2'',2'''-[[2-(4-aminophenyl)ethylimino]bis(methylene)bis[4-({4-[(methoxycarbonyl)methoxy]phenyl}ethynyl)pyridine-6,2-diyl]bis(methylenenitrilo)]tetrakis(acetate) 

Relevant articles and documents

Preparation of n-boc-(2,6-bis-(ethoxycarbonyl)pyridin 4-yl)-L-alanines as tridentate ligands

The pyridylalanine 7a was synthesised in good yield from serine and 4- bromopyridine 3. The pyridylpropionates 12, 13 were synthesised in good yields by either Heckolefination or palladium catalysed cross coupling.

Design, synthesis and structural investigation of a 1-D directional coordination network based on the self-assembly of an unsymmetrical mono-tridentate ligand and cobalt cation

Using an exo ligand containing a pyridine unit as a monodentate coordination site and a PyS2 moiety as a tridentate coordination pole, a directional 1-D coordination network has been obtained in the presence of CoCl2 under self-assembly conditions; a single-crystal X-ray study revealed that in the crystalline phase the 1-D networks are packed in a centrosymmetric fashion.

Synthesis of Homoditopic Ligands with an Incrementable Rodlike Backbone

We describe the synthesis of architectures that consist of a symmetrical rodlike oligo(phenylene-ethynylene) (OPE) backbone of incrementable length connected to a pair of classical ligands for metal coordination. OPE spacers decorated with various end gro

The Synthesis of Group 10 and 11 Metal Complexes of 3,6,9-Trithia-1-(2,6)-pyridinacyclodecaphane and Their Use in A3-Coupling Reactions

The reaction between 3,6,9-trithia-1(2,6)-pyridinacyclodecaphane and representative group 10 and 11 metal salts [Cu(NO3)2, NiCl2 or Ag(CF3CO2)] afforded 1:1 complexes, which in the case of CuII and AgI were characterised by single-crystal X-ray crystallography. The catalytic activity of these complexes in A3-coupling reactions between aldehydes, terminal alkynes and amines was assessed in both protic (water) and aprotic (toluene) media. These A3-reactions prove to be more efficient, proceed with lower catalyst loadings and with faster reaction rates, when conducted in a focused microwave reactor as compared to the same reactions promoted by standard, thermal, modes of activation.

Site-specific labeling of proteins with a chemically stable, high-affinity tag for protein study

Site-specific labeling of proteins with paramagnetic lanthanides offers unique opportunities by virtue of NMR spectroscopy in structural biology. In particular, these paramagnetic data, generated by the anisotropic paramagnetism including pseudocontact shifts (PCS), residual dipolar couplings (RDC), and paramagnetic relaxation enhancement (PRE), are highly valuable in structure determination and mobility studies of proteins and protein-ligand complexes. Herein, we present a new way to label proteins in a site-specific manner with a high-affinity and chemically stable tag, 4-vinyl(pyridine-2,6-diyl) bismethylenenitrilo tetrakis(acetic acid) (4VPyMTA), through thiol alkylation. Its performance has been demonstrated in G47C and E64C mutants of human ubiquitin both in vitro and in a crowded environment. In comparison with the published tags, 4VPyMTA has several interesting features: 1)it has a very high binding affinity for lanthanides (higher than EDTA), 2)there is no heterogeneity in complexes with lanthanides, 3)the derivatized protein is stable and potentially applicable to the in situ analysis of proteins. NMR tag: Site-specific labeling of proteins with a high affinity, chemically stable lanthanide-binding tag for structural biology is presented (see figure). The protein-tag construct is an ideal system for the study of protein stability and self-assembly processes under in situ conditions. Copyright