1-[4-(4-Fluoro-phenyl)-2-phenylamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-ethanone

Base Information

Chemical Name:1-[4-(4-Fluoro-phenyl)-2-phenylamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-ethanone
CAS No.:148363-46-6
Molecular Formula:C₂₁H₁₉FN₄O
Molecular Weight:362.406
Hs Code.:

Synonyms:1-[4-(4-Fluoro-phenyl)-2-phenylamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-ethanone

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Chemical Property of 1-[4-(4-Fluoro-phenyl)-2-phenylamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-ethanone

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Technology Process of 1-[4-(4-Fluoro-phenyl)-2-phenylamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-ethanone

There total 4 articles about 1-[4-(4-Fluoro-phenyl)-2-phenylamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 6522-91-4
N-phenyl-guanidine hydrochloride

: 1027568-90-6
1-Acetyl-3-[1-(4-fluoro-phenyl)-1-pyrrolidin-1-yl-meth-(Z)-ylidene]-piperidin-4-one

: 148363-46-6
1-[4-(4-Fluoro-phenyl)-2-phenylamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-ethanone

Guidance literature:: With sodium ethanolate; In ethanol; for 3h; Heating;
DOI:10.1016/0223-5234(92)90085-F

Reference yield:

: 55459-60-4
1-(4-(morpholin-4-yl)-3,6-dihydro-2H-pyridin-1-yl)ethanone

: 148363-46-6
1-[4-(4-Fluoro-phenyl)-2-phenylamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 0 - 20 °C

2: 5percent HCl / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 44 percent / toluene / 3 h / Ambient temperature

4: 45 percent / C₂H₅ONa / ethanol / 3 h / Heating

With hydrogenchloride; sodium ethanolate; triethylamine; In ethanol; dichloromethane; toluene;
DOI:10.1016/0223-5234(92)90085-F

Reference yield:

: 87642-26-0
1-Acetyl-3-(4-fluoro-benzoyl)-piperidin-4-one

: 148363-46-6
1-[4-(4-Fluoro-phenyl)-2-phenylamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 44 percent / toluene / 3 h / Ambient temperature

2: 45 percent / C₂H₅ONa / ethanol / 3 h / Heating

With sodium ethanolate; In ethanol; toluene;
DOI:10.1016/0223-5234(92)90085-F