7-chloro-1-(2,4-difluorobenzyl)-3-[2-fluoro-3-(trifluoromethyl)phenyl]cinnolin-4(1H)-one

Base Information

Chemical Name:7-chloro-1-(2,4-difluorobenzyl)-3-[2-fluoro-3-(trifluoromethyl)phenyl]cinnolin-4(1H)-one
CAS No.:1204652-82-3
Molecular Formula:C₂₂H₁₁ClF₆N₂O
Molecular Weight:468.786
Hs Code.:

Synonyms:7-chloro-1-(2,4-difluorobenzyl)-3-[2-fluoro-3-(trifluoromethyl)phenyl]cinnolin-4(1H)-one

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Chemical Property of 7-chloro-1-(2,4-difluorobenzyl)-3-[2-fluoro-3-(trifluoromethyl)phenyl]cinnolin-4(1H)-one

Chemical Property:

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Technology Process of 7-chloro-1-(2,4-difluorobenzyl)-3-[2-fluoro-3-(trifluoromethyl)phenyl]cinnolin-4(1H)-one

There total 7 articles about 7-chloro-1-(2,4-difluorobenzyl)-3-[2-fluoro-3-(trifluoromethyl)phenyl]cinnolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2-fluoro-3-(trifluoromethyl)phenyl)boronic acid

: 1204652-87-8
3-bromo-7-chloro-1-(2,4-difluorobenzyl)cinnolin-4(1H)-one

: 1204652-82-3
7-chloro-1-(2,4-difluorobenzyl)-3-[2-fluoro-3-(trifluoromethyl)phenyl]cinnolin-4(1H)-one

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; toluene; at 80 ℃; Inert atmosphere;

Reference yield:

: 1204652-83-4
tert-butyl (2-acetyl-5-chlorophenyl)carbamate

: 1204652-82-3
7-chloro-1-(2,4-difluorobenzyl)-3-[2-fluoro-3-(trifluoromethyl)phenyl]cinnolin-4(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C

2.1: hydrogenchloride; sodium nitrite / water / 2 h / 0 - 20 °C

3.1: potassium ethoxide / acetic acid / Reflux

3.2: 3 h / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 75 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; methanol / 80 °C / Inert atmosphere

With hydrogenchloride; potassium ethoxide; sodium hydride; sodium carbonate; trifluoroacetic acid; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 18514-89-1
7-chloro-1H-cinnolin-4-one

: 1204652-82-3
7-chloro-1-(2,4-difluorobenzyl)-3-[2-fluoro-3-(trifluoromethyl)phenyl]cinnolin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium ethoxide / acetic acid / Reflux

1.2: 3 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 75 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; methanol / 80 °C / Inert atmosphere

With potassium ethoxide; sodium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; acetic acid; N,N-dimethyl-formamide; toluene; mineral oil;