tert-butyl ((3S)-1-(4-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)-5-isothiazolyl)-3-piperidinyl)carbamate

Base Information

Chemical Name:tert-butyl ((3S)-1-(4-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)-5-isothiazolyl)-3-piperidinyl)carbamate
CAS No.:1405128-88-2
Molecular Formula:C₂₅H₂₇F₂N₇O₂S
Molecular Weight:527.598
Hs Code.:

Synonyms:tert-butyl ((3S)-1-(4-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)-5-isothiazolyl)-3-piperidinyl)carbamate

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Chemical Property of tert-butyl ((3S)-1-(4-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)-5-isothiazolyl)-3-piperidinyl)carbamate

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Technology Process of tert-butyl ((3S)-1-(4-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)-5-isothiazolyl)-3-piperidinyl)carbamate

There total 10 articles about tert-butyl ((3S)-1-(4-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)-5-isothiazolyl)-3-piperidinyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1405127-64-1
3-(azidomethyl)-6-(2,6-difluorophenyl)pyridazine

: 1405127-94-7
tert-butyl ((3S)-1-(4-isothiocyanato-5-isothiazolyl)-3-piperidinyl)carbamate

: 1405128-88-2
tert-butyl ((3S)-1-(4-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)-5-isothiazolyl)-3-piperidinyl)carbamate

Guidance literature:: 3-(azidomethyl)-6-(2,6-difluorophenyl)pyridazine; With trimethylphosphane; In tetrahydrofuran; for 0.25h; Inert atmosphere; Cooling;

tert-butyl ((3S)-1-(4-isothiocyanato-5-isothiazolyl)-3-piperidinyl)carbamate; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1618-47-9
3-iodo-6-methylpyridazine

: 1405128-88-2
tert-butyl ((3S)-1-(4-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)-5-isothiazolyl)-3-piperidinyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis[di-tert-butyl-(4-dimethylaminophenyl)phosphine]palladium (II) dichloride / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere; Sealed tube

2.1: trichloroisocyanuric acid / 1,2-dichloro-ethane / 90 °C

3.1: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C

4.1: trimethylphosphane / tetrahydrofuran / 0.25 h / Inert atmosphere; Cooling

4.2: 20 °C

With sodium azide; trichloroisocyanuric acid; trimethylphosphane; bis[di-tert-butyl-(4-dimethylaminophenyl)phosphine]palladium (II) dichloride; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1121-79-5
3-chloro-6-methylpyridazine

: 1405128-88-2
tert-butyl ((3S)-1-(4-((2-(2,6-difluorophenyl)imidazo[1,5-b]pyridazin-7-yl)amino)-5-isothiazolyl)-3-piperidinyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen iodide / water / 2 h / 100 °C

2.1: bis[di-tert-butyl-(4-dimethylaminophenyl)phosphine]palladium (II) dichloride / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere; Sealed tube

3.1: trichloroisocyanuric acid / 1,2-dichloro-ethane / 90 °C

4.1: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C

5.1: trimethylphosphane / tetrahydrofuran / 0.25 h / Inert atmosphere; Cooling

5.2: 20 °C

With sodium azide; trichloroisocyanuric acid; hydrogen iodide; trimethylphosphane; bis[di-tert-butyl-(4-dimethylaminophenyl)phosphine]palladium (II) dichloride; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;