6-(2-chloro-4-(3-methylpyrazin-2-yl)phenyl)-8-cyclopentyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

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Chemical Name:6-(2-chloro-4-(3-methylpyrazin-2-yl)phenyl)-8-cyclopentyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one
CAS No.:1432909-96-0
Molecular Formula:C₂₄H₂₂ClN₅O₂S
Molecular Weight:479.99
Hs Code.:

Synonyms:6-(2-chloro-4-(3-methylpyrazin-2-yl)phenyl)-8-cyclopentyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

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Chemical Property of 6-(2-chloro-4-(3-methylpyrazin-2-yl)phenyl)-8-cyclopentyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

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Technology Process of 6-(2-chloro-4-(3-methylpyrazin-2-yl)phenyl)-8-cyclopentyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

There total 14 articles about 6-(2-chloro-4-(3-methylpyrazin-2-yl)phenyl)-8-cyclopentyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432909-95-9
6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-cyclopentyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

: 1432909-96-0
6-(2-chloro-4-(3-methylpyrazin-2-yl)phenyl)-8-cyclopentyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 211245-63-5
[4-cyclopentylamino-2-(methylsulfanyl)pyrimidine-5-yl]methanol

: 1432909-96-0
6-(2-chloro-4-(3-methylpyrazin-2-yl)phenyl)-8-cyclopentyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: manganese(IV) oxide / dichloromethane / 18 h / Reflux

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 5 °C

2.2: 6 h / 0 - 20 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C

4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / toluene; tetrahydrofuran; water / 15 h / 100 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

With manganese(IV) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; potassium acetate; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 211245-64-6
4-cyclopentylamino-2-methylsulfanyl-pyrimidine-5-carbaldehyde

: 1432909-96-0
6-(2-chloro-4-(3-methylpyrazin-2-yl)phenyl)-8-cyclopentyl-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 5 °C

1.2: 6 h / 0 - 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / toluene; tetrahydrofuran; water / 15 h / 100 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; potassium acetate; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; toluene;