3-[2-[3-amino-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]ethynyl]phenol

Base Information

Chemical Name:3-[2-[3-amino-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]ethynyl]phenol
CAS No.:1350351-34-6
Molecular Formula:C₂₁H₁₉N₃O₃S
Molecular Weight:393.466
Hs Code.:

Synonyms:3-[2-[3-amino-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]ethynyl]phenol

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Chemical Property of 3-[2-[3-amino-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]ethynyl]phenol

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Technology Process of 3-[2-[3-amino-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]ethynyl]phenol

There total 8 articles about 3-[2-[3-amino-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]ethynyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1350351-50-6
3-[2-(3-amino-6-bromo-pyrazin-2-yl)ethynyl]phenol

: 1350351-52-8
4,4,5,5-tetramethyl-2-(4-tetrahydropyran-4-ylsulfonylphenyl)-1,3,2-dioxaborolane

: 1350351-34-6
3-[2-[3-amino-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]ethynyl]phenol

Guidance literature:: With potassium phosphate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In water; acetonitrile; at 60 ℃; for 15h;

Reference yield: 68.0%

: 10401-11-3
3-hydroxy phenylacetylene

: 1349151-83-2
3-bromo-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-amine

: 1350351-34-6
3-[2-[3-amino-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]ethynyl]phenol

Guidance literature:: With triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 1.5h; Sealed tube;

Reference yield:

: 106-53-6
para-bromobenzenethiol

: 1350351-34-6
3-[2-[3-amino-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]ethynyl]phenol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.75 h / 0 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

4: potassium phosphate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / acetonitrile; water / 15 h / 60 °C

With potassium phosphate; potassium acetate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;